A9850
Monoclonal Anti-Angiogenin antibody produced in mouse
clone 14017, purified immunoglobulin, lyophilized powder
别名:
Anti-ANG
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关于此项目
Conjugate:
unconjugated
Clone:
14017, monoclonal
Application:
ELISA (c), WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
14017, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
capture ELISA: 2-8 μg/mL, western blot: 1-2 μg/mL
isotype
IgG1
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ANG(283)
General description
Angiogenin (ANG) is a member of the ribonuclease superfamily that regulates blood vessel formation. ANG also modulates motor neuron physiology and the secretion of prostacyclin in endothelial cells. Mutations in ANG have been associated with amyotrophic lateral sclerosis . Monoclonal anti-angiogenin antibody is specific for recombinant human angiogenin.
Immunogen
purified recombinant human angiogenin expressed in E. coli.
Application
Monoclonal anti-angiogenin antibody is suitable for use in capture ELISA (2-8 μg/mL), immunoblot and western blot (1-2 μg/ml).
Monoclonal mouse anti-angiogenin was used for detection of angiogenin-I in mouse livers following induced myocardial ischemia by immunohistochemistry at a dilution of 1:1000.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
Jian-Xiong Chen et al.
Diabetes, 57(12), 3335-3343 (2008-10-07)
Diabetic impaired angiogenesis is associated with impairment of hypoxia-inducible factor-1alpha (HIF-1alpha) as well as vasculature maturation. We investigated the potential roles and intracellular mechanisms of angiopoietin-1 (Ang-1) gene therapy on myocardial HIF-1alpha stabilization and vascular maturation in db/db mice. db/db
M Moenner et al.
European journal of biochemistry, 226(2), 483-490 (1994-12-01)
Angiogenin is a secreted polypeptide that induces neovascularization in vivo. The expression of angiogenin by human cells in culture was investigated by using a specific radioimmunoassay and by cDNA hybridization. Angiogenin immunoreactivity was widely but differentially produced by anchorage-dependent growing
Aditya K Padhi et al.
PloS one, 7(2), e32479-e32479 (2012-03-03)
Mutations in the coding region of angiogenin (ANG) gene have been found in patients suffering from Amyotrophic Lateral Sclerosis (ALS). Neurodegeneration results from the loss of angiogenic ability of ANG (protein coded by ANG). In this work, we performed extensive
R Bicknell et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(5), 1573-1577 (1989-03-01)
Angiogenin stimulates capillary and umbilical vein endothelial cell prostacyclin secretion but not that of prostaglandins of the E series. The response was quantitated by radioimmunoassay and by [3H]arachidonate labeling followed by analysis of the secreted prostaglandins. The stimulated secretion lasts
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