生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
分子量
42 kDa
种属反应性
human, rat, bovine, rabbit, canine, mouse
技术
immunohistochemistry: suitable
western blot: suitable
免疫原序列
EVKPPPGRPQPDSGRRRRRRGEEGHDPKEPEQLRKLFIGGLSFETTDDSL
NCBI登记号
储存温度
−20°C
基因信息
human ... HNRPA3(220988)
一般描述
Heterogeneous Nuclear Ribonucleoproteins (hnRNP) are RNA binding proteins that form complexes with heterogeneous nuclear RNA (hnRNA). HnRNPs regulate pre-mRNA processing, metabolism and nuclear cytoplasmic shuttling. Specific HnRNPs have unique nucleic acid binding properties. Heterogeneous Nuclear Ribonucleoprotein A3 interacts with the regulatory region of Hoxc8 gene, which is involved in the regulation of the anterior-posterior axis in developing embryos.
免疫原
synthetic peptide corresponding to a region of human HNRPA3 with an internal ID of P22570
应用
Anti-HNRPA3 (AB1) polyclonal antibody is used to tag the heterogeneous nuclear ribonucleoprotein A3 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of heterogeneous nuclear ribonucleoprotein A3 in processes such as embryogenesis.
生化/生理作用
Anti-HNRPA3 (AB1) polyclonal antibody reacts with canine, human, mouse, rat, and bovine Heterogeneous Nuclear Ribonucleoprotein A3 proteins.
外形
Lyophilized from PBS buffer with 2% sucrose
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Yvonne S Davidson et al.
Acta neuropathologica communications, 5(1), 31-31 (2017-04-23)
Frontotemporal Lobar Degeneration (FTLD) encompasses certain related neurodegenerative disorders which alter behaviour, personality and language. Heterogeneous ribonuclear proteins (hnRNPs) maintain RNA metabolism and changes in their function may underpin the pathogenesis of FTLD. Immunostaining for hnRNP A1, A2/B1 and A3
Kohji Mori et al.
EMBO reports, 17(9), 1314-1325 (2016-07-28)
Intronic hexanucleotide (G4C2) repeat expansions in C9orf72 are genetically associated with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat RNA accumulates within RNA foci but is also translated into disease characterizing dipeptide repeat proteins (DPR). Repeat-dependent toxicity
Steven Boeynaems et al.
Scientific reports, 6, 20877-20877 (2016-02-13)
Hexanucleotide repeat expansions in C9orf72 are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) (c9ALS/FTD). Unconventional translation of these repeats produces dipeptide repeat proteins (DPRs) that may cause neurodegeneration. We performed a modifier screen in
Yang Li et al.
Brain research, 1647, 79-93 (2016-03-17)
The pathological accumulation of RNA-binding proteins (RBPs) within inclusion bodies is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). RBP aggregation results in both toxic gain and loss of normal function. Determining the protein binding partners
Yoshihiro Nihei et al.
Acta neuropathologica, 139(1), 99-118 (2019-10-24)
Repeat expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Expanded sense and antisense repeat RNA transcripts in C9orf72 are translated into five dipeptide-repeat proteins (DPRs) in an AUG-independent manner. We previously identified the heterogeneous ribonucleoprotein (hnRNP) A3
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