B012
6-Fluoronorepinephrine hydrochloride
solid
别名:
6-FNE
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关于此项目
经验公式（希尔记法）:
C8H10FNO3 · HCl
化学文摘社编号:
分子量:
223.63
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
产品名称
6-Fluoronorepinephrine hydrochloride, solid
InChI
1S/C8H10FNO3.ClH/c9-5-2-7(12)6(11)1-4(5)8(13)3-10;/h1-2,8,11-13H,3,10H2;1H
SMILES string
FC1=CC(O)=C(O)C=C1C(O)CN.[H]Cl
InChI key
QGDCLYPALFHCCD-UHFFFAOYSA-N
form
solid
color
off-white
solubility
H2O: soluble
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Adrb2(24176)
Biochem/physiol Actions
α-adrenoceptor agonist.
Disclaimer
Photosensitive. Solutions slowly oxidize in light/oxygen in a manner comparable to norepinephrine hydrochloride.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
R C Ferry et al.
The Journal of biological chemistry, 269(50), 31850-31857 (1994-12-16)
Exposure of P11 cells to serotonin (5-HT) resulted in a transient increase in levels of 5-HT2A receptor mRNA. Exposure to 5-HT for as short a time as 1 min was sufficient to trigger a delayed increase in receptor mRNA. 5-HT-induced
A Pilc et al.
Brain research, 493(1), 8-13 (1989-07-24)
Intraperitoneal administration of 0.8 mg/kg N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) to rats significantly reduced alpha-adrenoceptor binding in cerebral cortical membranes without affecting beta-adrenoceptor sites. A selective reduction in alpha 1-adrenoceptors was achieved by injecting yohimbine prior to EEDQ, whereas prazosin pretreatment yielded a
Eric A Stone et al.
The international journal of neuropsychopharmacology, 14(3), 319-331 (2010-05-13)
The present study examined the ability of 6-fluoronorepinephrine (6FNE), a full selective α-adrenoceptor agonist, to produce antidepressant-like effects in mice. The drug, administered in the 4th ventricle, produced marked anti-immobility effects at mid-dose range in the acute forced swim, tail
D Cantacuzene et al.
Science (New York, N.Y.), 204(4398), 1217-1219 (1979-06-15)
Substitution of fluorine for hydrogen in position 2, 5, or 6 of the aromatic ring of norepinephrine markedly alters the alpha- and beta-adrenergic agonist properties of norephinephrine. The 6-fluoro isomer is an beta-adrenergic agonist with virtually no beta agonist activity
Robert Papay et al.
The Journal of comparative neurology, 497(2), 209-222 (2006-05-18)
alpha(1)-Adrenergic receptors (ARs) are not well defined in the central nervous system. The particular cell types and areas that express these receptors are uncertain because of the lack of high avidity antibodies and selective ligands. We have developed transgenic mice
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