B0383
苯偶酰
别名:
联苯甲酰, 联苯酰
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线性分子式:
C6H5COCOC6H5
化学文摘社编号:
分子量:
210.23
EC Number:
205-157-0
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
608047
MDL number:
InChI key
WURBFLDFSFBTLW-UHFFFAOYSA-N
InChI
1S/C14H10O2/c15-13(11-7-3-1-4-8-11)14(16)12-9-5-2-6-10-12/h1-10H
SMILES string
O=C(c1ccccc1)C(=O)c2ccccc2
vapor pressure
1 mmHg ( 128.4 °C)
mp
94-95 °C (lit.)
Gene Information
human ... ACHE(43), BCHE(590), CES1(1066)
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
356.0 °F - closed cup
flash_point_c
180 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Craig E Wheelock et al.
Bioorganic & medicinal chemistry, 16(4), 2114-2130 (2007-11-21)
Carboxylesterases metabolize numerous exogenous and endogenous ester-containing compounds including the chemotherapeutic agent CPT-11, anti-influenza viral agent oseltamivir, and many agrochemicals. Trifluoromethyl ketone (TFK)-containing compounds with a sulfur atom beta to the ketone moiety are some of the most potent carboxylesterase
Janice L Hyatt et al.
Journal of medicinal chemistry, 48(17), 5543-5550 (2005-08-19)
Benzil has been identified as a potent selective inhibitor of carboxylesterases (CEs). Essential components of the molecule required for inhibitory activity include the dione moiety and the benzene rings, and substitution within the rings affords increased selectivity toward CEs from
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Latorya D Hicks et al.
Bioorganic & medicinal chemistry, 15(11), 3801-3817 (2007-04-03)
We have synthesized and assessed the ability of symmetrical fluorobenzoins and fluorobenzils to inhibit mammalian carboxylesterases (CE). The majority of the latter were excellent inhibitors of CEs however unexpectedly, the fluorobenzoins were very good enzyme inhibitors. Positive correlations were seen
Elizabeth I Parkinson et al.
Bioorganic & medicinal chemistry, 19(15), 4635-4643 (2011-07-08)
Carboxylesterases (CE) are ubiquitous enzymes found in both human and animal tissues and are responsible for the metabolism of xenobiotics. This includes numerous natural products, as well as a many clinically used drugs. Hence, the activity of these agents is
Janice L Hyatt et al.
Journal of medicinal chemistry, 50(23), 5727-5734 (2007-10-19)
Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of xenobiotics, including numerous clinically used drugs. Therefore, the selective inhibition of these proteins may prove useful in modulating drug half-life and bioavailability. Recently, we identified 1,2-diones as potent inhibitors of
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