B161
B-HT 933 dihydrochloride
≥98% (HPLC), solid
别名:
6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride, Azepexole dihydrochloride
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关于此项目
经验公式（希尔记法）:
C9H15N3O · 2HCl
化学文摘社编号:
分子量:
254.16
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
产品名称
B-HT 933 dihydrochloride, ≥98% (HPLC), solid
InChI
1S/C9H15N3O.2ClH/c1-2-12-5-3-7-8(4-6-12)13-9(10)11-7;;/h2-6H2,1H3,(H2,10,11);2*1H
SMILES string
Cl.Cl.CCN1CCc2nc(N)oc2CC1
InChI key
HBLPYIOKPJVFQW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
H2O: >20 mg/mL
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
Biochem/physiol Actions
Selective α2-adrenoceptor agonist.
Features and Benefits
This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
G P Nase et al.
The American journal of physiology, 274(1 Pt 2), H202-H208 (1998-02-12)
The purpose of this study was to evaluate two potential stimuli for nitric oxide (NO) release in rat intestinal arterioles during sympathetic nerve activation. To determine whether these vessels contain endothelial alpha 2-adrenoceptors linked to the L-arginine-NO pathway, intravital microscopy
S E Browne et al.
Brain research, 666(2), 216-222 (1994-12-15)
The anti-hypertensive drug, rilmenidine, has activity at both imidazoline-preferring receptors (IPRs) and alpha 2-adrenoceptors. However, available evidence suggests that its hypotensive effect is mediated via central IPRs. In the present study, the neuroanatomical regions involved in mediating the hypotensive response
Ma Trinidad Villamil-Hernández et al.
European journal of pharmacology, 691(1-3), 118-124 (2012-06-21)
It has been shown that α(2)-adrenoceptors mediate vasopressor responses in pithed rats. However, the corresponding α(2)-adrenoceptor subtypes have not been pharmacologically identified. Thus, this study set out to identify the specific subtypes (α(2A), α(2B) and α(2C)) mediating the vasopressor responses
Luis E Cobos-Puc et al.
European journal of pharmacology, 616(1-3), 175-182 (2009-06-17)
This study analysed the inhibition produced by the agonists moxonidine (imidazoline I(1) receptors>alpha(2)-adrenoceptors) and agmatine (endogenous ligand of imidazoline I(1)/I(2) receptors), using B-HT 933 (6-ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride; alpha(2)-adrenoceptors) for comparison, on the rat cardioaccelerator sympathetic outflow. Male Wistar rats were pithed
David M Keller et al.
The Journal of physiology, 588(Pt 19), 3799-3808 (2010-08-10)
This study tested the hypothesis that passive leg heating attenuates α-adrenergic vasoconstriction within that limb. Femoral blood flow (FBF, femoral artery ultrasound Doppler) and femoral vascular conductance (FVC, FBF/mean arterial blood pressure), as well as calf muscle blood flow (CalfBF
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