B161
B-HT 933 dihydrochloride
≥98% (HPLC), solid
别名:
6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride, Azepexole dihydrochloride
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关于此项目
经验公式（希尔记法）:
C9H15N3O · 2HCl
化学文摘社编号:
分子量:
254.16
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
方案
≥98% (HPLC)
表单
solid
颜色
white to off-white
溶解性
H2O: >20 mg/mL
SMILES字符串
Cl.Cl.CCN1CCc2nc(N)oc2CC1
InChI
1S/C9H15N3O.2ClH/c1-2-12-5-3-7-8(4-6-12)13-9(10)11-7;;/h2-6H2,1H3,(H2,10,11);2*1H
InChI key
HBLPYIOKPJVFQW-UHFFFAOYSA-N
基因信息
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
生化/生理作用
Selective α2-adrenoceptor agonist.
特点和优势
This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
H Kurvers et al.
Acta orthopaedica Belgica, 64(1), 64-70 (1998-05-20)
Sciatic nerve ligation in rats (chronic constriction injury (CCI)) induces clinical signs and symptoms that mimic human conditions of neuropathic origin, such as reflex sympathetic dystrophy (RSD). Denervation-induced supersensitivity to (circulating) catecholamines has been implicated in sympathetic dysfunction in the
Enrique F Castillo et al.
Fundamental & clinical pharmacology, 20(4), 339-349 (2006-07-27)
In rat aorta, the presence of functional alpha(2)-adrenoceptors (alpha(2)-AR) was investigated in ring preparations preconstricted with alpha(1)-adrenergic and non- alpha(1)-adrenergic agonists. Particularly, the hypothetical interference of alpha(2)-AR agonists with alpha(1)-AR-mediated vasoconstriction was evaluated. Relaxant and contractile responses to alpha(2)-AR agonists
T V Hoang et al.
Journal of pediatric surgery, 31(12), 1659-1662 (1996-12-01)
To characterize neonatal mesenteric alpha-adrenoceptor populations, an extracorporeal perfusion circuit was established to control intestinal blood flow in prematurely delivered (by cesarean section at 90% of gestational age) piglets. Activation of alpha 1-adrenoceptors was documented by observing dose-dependent increases in
G Lembo et al.
The Journal of clinical investigation, 100(8), 2007-2014 (1997-10-23)
We explored in 51 normal subjects, distributed in various series of experiments, whether endothelium nitric oxide may play a role in insulin modulation of alpha2- and beta-adrenergic- evoked vascular responses. In particular, we examined the forearm blood flow response (FBF
Sensitization of coronary alpha-adrenoceptor vasoconstriction in the prediabetic metabolic syndrome.
U Deniz Dincer et al.
Microcirculation (New York, N.Y. : 1994), 13(7), 587-595 (2006-09-23)
This study tested whether alpha -adrenoceptor-mediated coronary vasoconstriction is augmented in the metabolic syndrome and is accompanied by the alteration of specific alpha(1)- and alpha(2)-coronary adrenoceptors. Studies were conducted in control and chronically high-fat-fed (6 weeks of 60% calories from
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