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Merck
CN

B1636

Sigma-Aldrich

五肽胃泌素

≥95% (HPLC), powder, CCK2 receptor agonist

别名:

五肽促胃酸激素, 五肽胃泌素, N-t-Boc-β-Ala-Trp-Met-Asp-Phe酰胺

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关于此项目

经验公式（希尔记法）:
C37H49N7O9S
化学文摘社编号:
5534-95-2
分子量:
767.89
EC 号:
226-889-7
MDL编号:
MFCD00076515
UNSPSC代码:
12352200
PubChem化学物质编号:
24891602
NACRES:
NA.77

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产品名称

五肽胃泌素, ≥95% (HPLC), powder

质量水平

200

方案

≥95% (HPLC)

表单

powder

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

颜色

white to off-white

溶解性

DMF: 20 mg/mL, clear, colorless to faint yellow or tan

储存温度

−20°C

SMILES字符串

CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O

InChI

1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)

InChI key

NEYNJQRKHLUJRU-UHFFFAOYSA-N

基因信息

mouse ... Cckbr(12426)
rat ... Cckar(24889), Cckbr(25706)

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相关类别

Amino Acid Sequence

Boc-Bal-Trp-Met-Asp-Phe-NH2

一般描述

适合研究领域：免疫学 & 细胞因子

应用

五肽胃泌素已被用于双向调节杏仁核外侧核(LA)的活力。在AR42J大鼠胰腺细胞系中，可阻断胆囊收缩素2受体(CCK2R)激动剂抑制受体与Ga-DOTA-MGS5的结合，进行细胞摄取和受体结合研究。

生化/生理作用

五肽胃泌素为人工合成的胃泌素类似物，肽链羧基末端五肽的结构与天然胃泌素一样。可作为胆囊收缩素-2(CCK2)受体/胆囊收缩素-B(CCKB)受体的激动剂。五肽胃泌素可促进胃蛋白酶和胃酸分泌，适合用于胃酸分泌功能检查。五肽胃泌素具有惊恐和焦虑作用，会导致惊恐症(PD)患者的惊恐发作。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000490783
0000490783
0000490782
0000490782
0000477184

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is Pentagastrin, Product B1636, soluble in?

    Pentagastrin is soluble in either dimethylformamide (DMF) or DMSO at a concentration of 20 mg/mL.

  4. How can Pentagastrin, Product B1636, solutions be stored?

    Pentagastrin is subject to oxidation in solution.  A pentagastrin solution in DMF can be stored frozen to protect the TRP and MET from oxidation. Further protection from oxidation can be insured if the solution is prepared with degassed solvent and the solution is stored under an inert gas such as argon or dry nitrogen gas.

  5. What is the shelf-life of Pentagastrin, Product B1636?

    This product does not have any official shelf-life or expiration dating associated with it. The only date shown on the certificate of analysis will be the QC Release date. For customers whose systems require formal date management, use of a date one year from shipment is supported by our terms and conditions of supply.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

L Singh et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(4), 1130-1133 (1991-02-15)
The effect of neuropeptide cholecystokinin (CCK) receptor agonists and antagonists was examined in the rat elevated X-maze model of anxiety. The selective CCK-B receptor antagonists CI-988 (PD 134308) and L-365,260 produced anxiolytic-like effects, whereas MK-329, a CCK-A receptor antagonist, was
Y Keto et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(2), 147-153 (2011-11-10)
Gastroduodenal acidification has been reported to aggravate upper abdominal discomfort and pain that are symptoms suffered by functional dyspepsia (FD) patients. Delayed gastric emptying and hypersensitivity to gastric distension (GD) contribute importantly to the pathophysiology of FD. In the present
T D Barrett et al.
British journal of pharmacology, 166(5), 1684-1693 (2012-02-04)
JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide] is a novel antagonist at cholecystokinin CCK(2) receptors with good pharmacokinetic properties and represents a novel mechanism for the treatment of gastro-oesophageal reflux disease (GORD). The purpose of the present study was to determine whether chronic treatment with
Makoto Inada et al.
Scandinavian journal of gastroenterology, 47(2), 148-154 (2012-01-05)
A traditional measurement of gastric acid, involving nasogastric intubation of stomach and acid suction, has been suggested as a gold standard. However, this causes the patient discomfort and cost increase, and is 'time-consuming'. A calcium [(13)C]carbonate (Ca(13)CO(3)) breath test was
Katsunori Iijima et al.
Journal of gastroenterology, 47(12), 1290-1297 (2012-05-03)
The association of Helicobacter pylori infection with aspirin-induced gastropathy is controversial. H. pylori infection exerts diverse effects on gastric acid secretion. In this study, the interaction between H. pylori infection and aspirin was investigated with reference to the individual gastric
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