B2643
生物素酰胺己酸 N-羟基琥珀酰亚胺酯
≥98% (TLC), powder
别名:
(+)-生物素氨基己酸酯 N-羟基琥珀酰亚胺酯, 6-己酸琥珀酰亚胺酯, N-(+)-生物素-6-氨基己酸 N-琥珀酰亚胺酯, N-(+)-生物素-6-氨基己酸 NHS 酯, N-琥珀酰亚胺基 N-生物素基-6-氨基己酸酯
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关于此项目
经验公式（希尔记法）:
C20H30N4O6S
化学文摘社编号:
分子量:
454.54
Beilstein:
3577403
MDL编号:
UNSPSC代码:
12352203
PubChem化学物质编号:
NACRES:
NA.46
质量水平
方案
≥98% (TLC)
表单
powder
溶解性
H2O: ≤2 mg/mL (with sonication)
DMF: 50 mg/mL (Stable up to 2 months in dry DMF.)
储存温度
−20°C
SMILES字符串
[H][C@]12CS[C@@H](CCCCC(=O)NCCCCCC(=O)ON3C(=O)CCC3=O)[C@@]1([H])NC(=O)N2
InChI
1S/C20H30N4O6S/c25-15(7-4-3-6-14-19-13(12-31-14)22-20(29)23-19)21-11-5-1-2-8-18(28)30-24-16(26)9-10-17(24)27/h13-14,19H,1-12H2,(H,21,25)(H2,22,23,29)/t13-,14-,19-/m0/s1
InChI key
UVGHPGOONBRLCX-NJSLBKSFSA-N
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应用
生物素氨基己酸N-羟基琥珀酰亚胺酯已用于抗体的生物素化。
生化/生理作用
生物素是一种广泛应用于生物化学领域的标签，与亲和素高度亲和。当将生物素（小分子）偶联到生物聚合物（大分子）时，需要一个间隔链来减少空间位阻。生物素氨基己酸 N-羟基琥珀酰亚胺酯含有一个7原子间隔基和N-琥珀酰亚胺离去基。它能与pH值在6.5-8.5范围内的伯胺反应。这种生物素化试剂含有氨基丙基间隔体，因此可以减少亲和素与某些生物素化化合物结合时的空间位阻。
免责声明
除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
C Hughes et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 3(4), 623-630 (2001-04-26)
Three strategies have been designed to concentrate infectious retroviral vectors from the supernatants of human- (HT1080) and murine- (NIH 3T3) based packaging cells. Streptavidin-conjugated paramagnetic particles in conjunction with (i) antibodies directed against murine fibronectin, (ii) biotinylated lectins, or (iii)
Heike M Pirner et al.
The Journal of biological chemistry, 281(18), 12381-12389 (2006-03-15)
Biotin is a water-soluble vitamin that functions as a prosthetic group in carboxylation reactions. In addition to its role as a cofactor, biotin has multiple roles in gene regulation. We analyzed biotin effects on gene expression in the yeast Saccharomyces
Alana M Thackray et al.
The Biochemical journal, 401(2), 475-483 (2006-10-05)
PrPSc [abnormal disease-specific conformation of PrP (prion-related protein)] accumulates in prion-affected individuals in the form of amorphous aggregates. Limited proteolysis of PrPSc results in a protease-resistant core of PrPSc of molecular mass of 27-30 kDa (PrP27-30). Aggregated forms of PrP
R Maya et al.
Genes & development, 15(9), 1067-1077 (2001-05-02)
The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing radiation and radiomimetic agents is largely dependent on the ATM kinase. p53
Vincent H B Ho et al.
Ultrasound in medicine & biology, 37(1), 169-175 (2010-11-19)
Magnetite (Fe(3)O(4)) nanoparticle agglomerates have been shown to enhance the degree of inertial cavitation induced by high-intensity focused ultrasound (HIFU). To investigate the effect of these particles on the destruction of tumor spheroids using HIFU, HeLa spheroids were insonated in
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