B5683
倍他洛尔 盐酸盐
>98% (HPLC), calcium channel blocker, solid
别名:
SL 75212
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关于此项目
经验公式（希尔记法）:
C18H29NO3 · HCl
化学文摘社编号:
分子量:
343.89
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
264-384-3
MDL number:
产品名称
倍他洛尔 盐酸盐, >98% (HPLC)
InChI
1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H
InChI key
CHDPSNLJFOQTRK-UHFFFAOYSA-N
SMILES string
Cl[H].CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1
assay
>98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
H2O: soluble 36 mg/mL
originator
Alcon
Quality Level
Gene Information
human ... ADRB1(153)
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Application
Betaxolol hydrochloride has been used as a β1 blocking agent:
- for the preparation of crystals of (R,S)-betaxolol (BE-IV).
- to treat mammalian cells prior cell stimulation experiments.
- to study the solid structure of metoprolol.
Biochem/physiol Actions
Betaxolol hydrochloride has the ability to block calcium channels. Betaxolol is a selective β1 adrenoreceptor antagonist. It has neuroprotective effects on retinal neurons.
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Alcon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
I A Latfullin et al.
Klinicheskaia meditsina, 88(2), 68-71 (2010-11-26)
The use of beta-blockers is an important component of therapy of cardiovascular pathology (e.g. coronary heart disease, arterial hypertension) in menopausal women. Comparative data on the efficiency of lokren and carvedilol for the correction of grade 2 AH are presented.
The solid-state structure of the beta-blocker metoprolol: a combined experimental and in silico investigation
Rossi P, et al.
Acta Crystallographica Section C, Structural Chemistry, 75(2) (2019)
Anders Heijl et al.
American journal of ophthalmology, 152(5), 842-848 (2011-08-17)
To analyze reduction of intraocular pressure (IOP) by argon laser trabeculoplasty (ALT) in the Early Manifest Glaucoma Trial and factors influencing the effect of such treatment. Cohort study based on 127 patients from the treatment group of the Early Manifest
Allergic contact dermatitis due to the beta-blocker betaxolol in eyedrops, with cross-sensitivity to timolol.
Massimiliano Nino et al.
Contact dermatitis, 62(5), 319-320 (2010-06-12)
Emmanuel Boucrot et al.
Nature, 517(7535), 460-465 (2014-12-18)
Endocytosis is required for internalization of micronutrients and turnover of membrane components. Endophilin has been assigned as a component of clathrin-mediated endocytosis. Here we show in mammalian cells that endophilin marks and controls a fast-acting tubulovesicular endocytic pathway that is
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