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安全信息

B5683

Sigma-Aldrich

倍他洛尔 盐酸盐

>98% (HPLC)

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别名:
SL 75212
经验公式（希尔记法）:
C18H29NO3 · HCl
CAS号:
63659-19-8
分子量:
343.89
EC 号:
264-384-3
MDL编号:
MFCD00242959
PubChem化学物质编号:
24278274
NACRES:
NA.77

检测方案

>98% (HPLC)

形式

solid

储存条件

desiccated

颜色

white

溶解性

H2O: soluble 36 mg/mL

创始人

Alcon

SMILES字符串

Cl[H].CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1

InChI

1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H

InChI key

CHDPSNLJFOQTRK-UHFFFAOYSA-N

基因信息

human ... ADRB1(153)

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应用

Betaxolol hydrochloride has been used as a β1 blocking agent:
  • for the preparation of crystals of (R,S)-betaxolol (BE-IV).
  • to treat mammalian cells prior cell stimulation experiments.
  • to study the solid structure of metoprolol.

生化/生理作用

Betaxolol hydrochloride has the ability to block calcium channels. Betaxolol is a selective β1 adrenoreceptor antagonist. It has neuroprotective effects on retinal neurons.

特点和优势

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Alcon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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Emmanuel Boucrot et al.
Nature, 517(7535), 460-465 (2014-12-18)
Endocytosis is required for internalization of micronutrients and turnover of membrane components. Endophilin has been assigned as a component of clathrin-mediated endocytosis. Here we show in mammalian cells that endophilin marks and controls a fast-acting tubulovesicular endocytic pathway that is
J P M Wood et al.
Experimental eye research, 76(4), 505-516 (2003-03-14)
beta-adrenoceptor antagonists are used clinically to reduce elevated intraocular pressure in glaucoma which is characterised by a loss of retinal ganglion cells. Previous studies have shown that the beta(1)-selective adrenoceptor antagonist, betaxolol, is additionally able to protect retinal neurones in
The beta-adrenoceptor antagonists metipranolol and timolol are retinal neuroprotectants: comparison with betaxolol
Wood J P M, et al.
Experimental Eye Research, 76(4) (2003)
I A Latfullin et al.
Klinicheskaia meditsina, 88(2), 68-71 (2010-11-26)
The use of beta-blockers is an important component of therapy of cardiovascular pathology (e.g. coronary heart disease, arterial hypertension) in menopausal women. Comparative data on the efficiency of lokren and carvedilol for the correction of grade 2 AH are presented.
The solid-state structure of the beta-blocker metoprolol: a combined experimental and in silico investigation
Rossi P, et al.
Acta Crystallographica Section C, Structural Chemistry, 75(2) (2019)
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