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Merck
CN

B7061

Sigma-Aldrich

Butyrylcholinesterase 人

recombinant, expressed in goat, ≥500 units/mg protein

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UNSPSC代码:
12352204
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重组

expressed in goat

比活

≥500 units/mg protein

UniProt登记号

运输

dry ice

储存温度

−70°C

基因信息

human ... BCHE(590)

应用

Butyrylcholinesterase (BChE) may be used to hydrolyze large esters of choline such as butyrylcholine and benzoylcholine. Selective inhibition of BChE activity can be used in the detection of organophosphates. BchE may be used to treat organophosphate toxicity. It may be a useful tool in Alzheimer′s research. BchE, from Sigma, has been used to determine butyrylcholinesterase inhibition by various test compounds .

生化/生理作用

Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. BChE is found in serum, hemopoietic cells, liver, lung, heart and in the central nervous system of vertebrates.

外形

Supplied as a solution in 10 mM sodium phosphate, pH 7.2 with 50 mM NaCl, 1 mM EDTA and 10% glycerol.

其他说明

One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.

象形图

Health hazard

警示用语:

Danger

危险声明

预防措施声明

危险分类

Resp. Sens. 1

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Kazuhide Miyamoto
Scientific reports, 4, 6574-6574 (2014-10-11)
The artificial WSTF PHD_EL5 RING finger was designed via "α-helical region substitution", and its structural model for the attachment of activated ubiquitin has been demonstrated. Chemical modifications of Cys residues, the circular dichroism spectra, and substrate-independent ubiquitination assays illustrated that
A I Sacaan et al.
The Journal of pharmacology and experimental therapeutics, 280(1), 373-383 (1997-01-01)
Nicotine, the prototypical agonist for neuronal nicotinic acetylcholine receptors (NAChR), nonselectively activates NAChR limiting its use in elucidating the function of NAChR subtypes. SIB-1765F is a subtype selective NAChR agonist that displaces [3H]-nicotine binding with an IC50 of 4.6 nM
Shiuh-Rong Ho et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), E2646-E2655 (2014-07-01)
Several ring between ring fingers (RBR) -domain proteins, such as Parkin and Parc, have been shown to be E3 ligases involved in important biological processes. Here, we identify a poorly characterized RBR protein, Ring Finger protein 144A (RNF144A), as the
Lingling Fan et al.
The Journal of biological chemistry, 290(34), 20865-20879 (2015-07-15)
Re-activation of androgen receptor (AR) activity is the main driver for development of castration-resistant prostate cancer. We previously reported that the ubiquitin ligase Siah2 enhanced AR transcriptional activity and prostate cancer cell growth. Among the genes we found to be
Irina Tikhanovich et al.
The Journal of biological chemistry, 290(36), 22236-22249 (2015-07-30)
Arginine methylation is a common post-translational modification, but its role in regulating protein function is poorly understood. This study demonstrates that, TNF receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase involved in innate immune signaling, is regulated by reversible arginine

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