Application
Butyrylcholinesterase (BChE) may be used to hydrolyze large esters of choline such as butyrylcholine and benzoylcholine. Selective inhibition of BChE activity can be used in the detection of organophosphates. BchE may be used to treat organophosphate toxicity. It may be a useful tool in Alzheimer′s research. BchE, from Sigma, has been used to determine butyrylcholinesterase inhibition by various test compounds .
Biochem/physiol Actions
Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. BChE is found in serum, hemopoietic cells, liver, lung, heart and in the central nervous system of vertebrates.
Physical form
Supplied as a solution in 10 mM sodium phosphate, pH 7.2 with 50 mM NaCl, 1 mM EDTA and 10% glycerol.
Other Notes
One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
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The Journal of pharmacology and experimental therapeutics, 280(1), 373-383 (1997-01-01)
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Proceedings of the National Academy of Sciences of the United States of America, 111(26), E2646-E2655 (2014-07-01)
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The Journal of biological chemistry, 290(36), 22236-22249 (2015-07-30)
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