B8061
N-丁基-N-（4-羟丁基）亚硝胺
ISOPAC®, ≥90% (GC)
别名:
BBN, N-丁基-N-(4-羟丁基)亚硝胺, N-丁基-N-丁-4-醇亚硝胺, N-丁基-N-亚硝基-4-氨基丁醇
质量水平
方案
≥90% (GC)
表单
liquid
储存温度
2-8°C
SMILES字符串
N(N=O)(CCCCO)CCCC
InChI
1S/C8H18N2O2/c1-2-3-6-10(9-12)7-4-5-8-11/h11H,2-8H2,1H3
InChI key
DIKPQFXYECAYPC-UHFFFAOYSA-N
应用
致癌物 N-丁基-N-（4-羟基丁基）亚硝胺（BBN）用于在动物模型中诱导病原学相关的侵袭性膀胱癌。
生化/生理作用
致癌物质用于在动物模型中诱导膀胱癌。暴露的结果在组织学上与人膀胱肿瘤发生相当。用于化学预防研究。
包装
100 mL 血清瓶封装，配有丁基橡胶塞和铝质撕裂密封。
制备说明
将内容物溶解在100mL溶剂中，可得到1％的溶液。
法律信息
Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
通过注入任何相容的溶剂可在不暴露内容物的情况下制备任何所需强度的溶液。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Carc. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
296.6 °F
闪点(°C)
147 °C
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ting-Tsz Ou et al.
Journal of ethnopharmacology, 135(1), 162-172 (2011-03-15)
Extracts of Paeonia lactiflora Pall (RPA), a traditional Chinese medicines has been shown to treat cancers. The purpose of this study is to evaluate the anticancer effect of RPA in urinary bladder carcinoma in vitro and in vivo. The cell
Zhiming He et al.
Mutation research, 742(1-2), 92-95 (2011-12-14)
Bladder cancer is one of the few cancers that have been linked to carcinogens in the environment and tobacco smoke. Of the carcinogens tested in mouse chemical carcinogenesis models, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) is one that reproducibly causes high-grade, invasive cancers in
Paul-Yann Lin et al.
Toxicology and applied pharmacology, 259(1), 27-37 (2011-12-20)
Epidemiological studies have revealed that exposure to an arsenic-contaminated environment correlates with the incidence of bladder cancer. Bladder cancer is highly recurrent after intravesical therapy, and most of the deaths from this disease are due to invasive metastasis. In our
Koji Nishizawa et al.
International journal of cancer, 127(5), 1180-1187 (2009-12-30)
We previously reported that the expression of CXC chemokine receptor-4 (CXCR4) was upregulated in invasive bladder cancers and that the small peptide T140 was a highly sensitive antagonist for CXCR4. In this study, we identified that CXCR4 expression was induced
Jun Miyazaki et al.
Anticancer research, 31(6), 2065-2071 (2011-07-09)
The present gold standard for bladder cancer is Mycobacterium bovis bacillus Calmette-Guérin (BCG) immunotherapy, but serious side-effects are common. We previously reported that C3H/HeN mice vaccinated with a mixture of MBT-2 cells and artificial BCG, octaarginine-modified liposomes incorporating the cell
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