B8061
N-丁基-N-（4-羟丁基）亚硝胺
ISOPAC®, ≥90% (GC)
别名:
BBN, N-丁基-N-(4-羟丁基)亚硝胺, N-丁基-N-丁-4-醇亚硝胺, N-丁基-N-亚硝基-4-氨基丁醇
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关于此项目
经验公式（希尔记法）:
C8H18N2O2
化学文摘社编号:
分子量:
174.24
MDL number:
UNSPSC Code:
12352116
NACRES:
NA.25
SMILES string
N(N=O)(CCCCO)CCCC
InChI
1S/C8H18N2O2/c1-2-3-6-10(9-12)7-4-5-8-11/h11H,2-8H2,1H3
InChI key
DIKPQFXYECAYPC-UHFFFAOYSA-N
assay
≥90% (GC)
form
liquid
storage temp.
2-8°C
Quality Level
Application
致癌物 N-丁基-N-（4-羟基丁基）亚硝胺（BBN）用于在动物模型中诱导病原学相关的侵袭性膀胱癌。
Biochem/physiol Actions
致癌物质用于在动物模型中诱导膀胱癌。暴露的结果在组织学上与人膀胱肿瘤发生相当。用于化学预防研究。
Packaging
100 mL 血清瓶封装，配有丁基橡胶塞和铝质撕裂密封。
Preparation Note
将内容物溶解在100mL溶剂中，可得到1％的溶液。
Legal Information
Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
通过注入任何相容的溶剂可在不暴露内容物的情况下制备任何所需强度的溶液。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
296.6 °F
flash_point_c
147 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Koji Nishizawa et al.
International journal of cancer, 127(5), 1180-1187 (2009-12-30)
We previously reported that the expression of CXC chemokine receptor-4 (CXCR4) was upregulated in invasive bladder cancers and that the small peptide T140 was a highly sensitive antagonist for CXCR4. In this study, we identified that CXCR4 expression was induced
Xiao-Li Xie et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(11), 3934-3940 (2012-08-15)
In the present study, effects of L-leucine and L-isoleucine on rat bladder carcinogenesis were investigated using AIN-93G and MF basal diet. In Experiment 1, N-butyl-N-(4-hydroxybutyl)-nitrosamine was used as an initiator of bladder carcinogenesis. In the AIN-93G diet groups, a significantly
Jun Miyazaki et al.
Anticancer research, 31(6), 2065-2071 (2011-07-09)
The present gold standard for bladder cancer is Mycobacterium bovis bacillus Calmette-Guérin (BCG) immunotherapy, but serious side-effects are common. We previously reported that C3H/HeN mice vaccinated with a mixture of MBT-2 cells and artificial BCG, octaarginine-modified liposomes incorporating the cell
Paul-Yann Lin et al.
Toxicology and applied pharmacology, 259(1), 27-37 (2011-12-20)
Epidemiological studies have revealed that exposure to an arsenic-contaminated environment correlates with the incidence of bladder cancer. Bladder cancer is highly recurrent after intravesical therapy, and most of the deaths from this disease are due to invasive metastasis. In our
Nelci Antunes de Moura et al.
Archives of toxicology, 84(2), 165-173 (2009-11-11)
The potential promoting effect of Diuron was investigated in a mouse model of mammary and urinary bladder carcinogenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA) and N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). Four-week old female Swiss mice were allocated to five groups: Groups G1-G3 received DMBA (5
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