生物来源
mouse
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
2H12, monoclonal
表单
buffered aqueous solution
分子量
antigen 27 kDa
种属反应性
rat, mouse, human
浓度
~2 mg/mL
技术
microarray: suitable
western blot: 25-100 μg/mL using human epidermoid carcinoma A431 cell extract
同位素/亚型
IgG2a
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... BCL2L1(598)
mouse ... Bcl2l1(12048)
rat ... Bcl2l1(24888)
免疫原
synthetic peptide corresponding to amino acids 3-14 shared by murine and human Bcl-xL, conjugated to KLH.
应用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
生化/生理作用
The antibody reacts with Bcl-xL protein, but not with Bcl-xS.
外形
Solution in phosphate buffered saline, pH 7.4 containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Peter F Vitiello et al.
Free radical biology & medicine, 44(3), 367-374 (2008-01-25)
The tumor suppressor protein p53 activates growth arrest and proapoptotic genes in response to DNA damage. It is known that negative feedback by p21(Cip1/Waf1/Sdi1) represses p53-dependent transactivation of PUMA. The current study investigates PUMA feedback on p53 during oxidative stress
Kenichiro Doi et al.
The Journal of biological chemistry, 287(13), 10224-10235 (2012-02-09)
The anti-apoptotic Bcl-2 family of proteins, including Bcl-2, Bcl-X(L) and Mcl-1, are well-validated drug targets for cancer treatment. Several small molecules have been designed to interfere with Bcl-2 and its fellow pro-survival family members. While ABT-737 and its orally active
A Notte et al.
Cell death & disease, 4, e638-e638 (2013-05-18)
Cancer cell resistance against chemotherapy is still a heavy burden to improve anticancer treatments. Autophagy activation and the development of hypoxic regions within the tumors are known to promote cancer cell resistance. Therefore, we sought to evaluate the role of
Vikash Kumar et al.
Oncotarget, 8(32), 53124-53136 (2017-09-09)
Ovarian cancer represents one of the most common malignancies among women with very high mortality rate worldwide. A-kinase anchor protein 4 (AKAP4), a unique cancer testis (CT) antigen has been shown to be associated with various malignant properties of cancer
L Zhang et al.
Cell death and differentiation, 18(5), 864-873 (2010-11-30)
The BH3-only proteins of the Bcl-2 family are known to mediate mitochondrial dysfunction during apoptosis. However, the identity of the critical BH3-only proteins and the mechanism of their action following treatment by diverse apoptotic stimuli remain to be fully resolved.
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