C0617
Anti-CLAN Protein (CARD12) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Caspase Recruitment Domain Protein 12, Anti-ICE-Protease Activating Factor (IPAF)
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~116 kDa (CLAN-A)
antigen ~40 kDa (CLAN-B)
种属反应性
human
技术
western blot: 1:500-1:1,000 using lung lysates
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... NLRC4(58484)
一般描述
NLR family CARD domain-containing protein 4 is a protein encoded by NLRC4 gene in humans. NLRC4 is also known as CLAN, IPAF, CLAN1, CLANA, CLANB, CLANC, CLAND, CARD12 and CLR2. It is a member of the Ced4/ Apaf-1 family.
免疫原
peptide corresponding to the N-terminus of the human CLAN protein, both A and B isoforms.
应用
Anti-CLAN Protein (CARD12) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:1,000 using human lung lysates.
生化/生理作用
CLAN (CARD12) induces apoptosis and plays a critical role in NF-κB signaling pathways. CARD12 plays an important role during activation of caspase-1 and is dependent on the nucleotide-binding site. It prevents motor-neuron apoptosis induced by a variety of signals.
外形
Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
B J Geddes et al.
Biochemical and biophysical research communications, 284(1), 77-82 (2001-05-26)
The CED4/Apaf-1 family of proteins functions as critical regulators of apoptosis and NF-kappaB signaling pathways. A novel human member of this family, called CARD12, was identified that induces apoptosis when expressed in cells. CARD12 is most similar in structure to
Chafen Lu et al.
Biochemical and biophysical research communications, 331(4), 1114-1119 (2005-05-11)
CARD12 (Ipaf/Clan) is an important regulator of caspase-1 activation. It belongs to the family of the nucleotide-binding site and leucine-rich repeat (NBS-LRR) proteins. The NBS domain of the NBS-LRR proteins contains putative ATP/GTPase-specific P-loop and Mg2+-binding site motifs. However, the
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