C101
8-环戊基-1,3-二丙基黄嘌呤
A1 adenosine receptor antagonist, solid
别名:
1,3-二丙基-8-环戊基黄嘌呤, DPCPX, PD 116948
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关于此项目
经验公式（希尔记法）:
C16H24N4O2
化学文摘社编号:
分子量:
304.39
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
产品名称
8-环戊基-1,3-二丙基黄嘌呤, solid
form
solid
Quality Level
color
white
solubility
DMSO: >10 mg/mL, 0.1 M NaOH: 2 mg/mL, ethanol: 4 mg/mL, H2O: insoluble
εmax
14,800 at 276 nm in ethanol
SMILES string
CCCN1C(=O)N(CCC)c2nc([nH]c2C1=O)C3CCCC3
InChI
1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
InChI key
FFBDFADSZUINTG-UHFFFAOYSA-N
Gene Information
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)
相关类别
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Lindsay Silva et al.
Neurotoxicology and teratology, 58, 88-100 (2016-02-24)
Adolescents who use marijuana are more likely to exhibit anxiety, depression, and other mood disorders, including psychotic-like symptoms. Additionally, the age at onset of use and the stress history of the individual can affect responses to cannabis. To examine the
Hongjie Chen et al.
Experimental hematology, 37(5), 533-538 (2009-04-21)
The control of expression of tumor necrosis factor-alpha (TNF-alpha) impacts a variety of processes during a stress response. Macrophages are a major source of TNF-alpha, the level of which is known to be regulated by adenosine. Previous studies highlighted the
Jordi Bonaventura et al.
Nature communications, 10(1), 4627-4627 (2019-10-13)
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular chemogenetic technology for manipulation of neuronal activity in uninstrumented awake animals with potential for human applications as well. The prototypical DREADD agonist clozapine N-oxide (CNO) lacks brain entry and
Daniela Patinha et al.
American journal of physiology. Renal physiology, 304(5), F614-F622 (2013-01-04)
Increased angiotensin II (ANG II) or adenosine can potentiate each other in the regulation of renal hemodynamics and tubular function. Diabetes is characterized by hyperfiltration, yet the roles of ANG II and adenosine receptors for controlling baseline renal blood flow
Mariachiara Zuccarini et al.
Purinergic signalling, 13(4), 429-442 (2017-06-16)
Epithelial to mesenchymal transition (EMT) occurs during embryogenesis or under pathological conditions such as hypoxia, injury, chronic inflammation, or tissue fibrosis. In renal tubular epithelial cells (MDCK), TGF-β1 induces EMT by reducing or increasing epithelial or mesenchymal marker expression, respectively.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 791423-250MG | 04061832939445 |
| C101-25MG | 04061833460269 |
| C101-25G | 04061832283579 |
| C101-100MG | 04061832089508 |
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