C1115
柯胺G
≥95% (HPLC), ß-amyloid aggregates probe, solid
别名:
4,4′-双（3-羧基-4-羟基苯偶氮）联苯 二钠盐
产品名称
柯胺G, ≥95% (HPLC), solid
方案
≥95% (HPLC)
表单
solid
颜色
, orange to red to very dark brown
溶解性
DMSO: ~4 mg/mL
储存温度
−20°C
SMILES字符串
[Na+].[Na+].Oc1ccc(cc1C([O-])=O)N=Nc2ccc(cc2)-c3ccc(cc3)N=Nc4ccc(O)c(c4)C([O-])=O
InChI
1S/C26H18N4O6.2Na/c31-23-11-9-19(13-21(23)25(33)34)29-27-17-5-1-15(2-6-17)16-3-7-18(8-4-16)28-30-20-10-12-24(32)22(14-20)26(35)36;;/h1-14,31-32H,(H,33,34)(H,35,36);;/q;2*+1/p-2
InChI key
AZOPGDOIOXKJRA-UHFFFAOYSA-L
相关类别
一般描述
柯胺G是一种刚果红羧酸衍生物。
生化/生理作用
β-淀粉样蛋白聚集体的新探针。
柯胺G可以穿过血脑屏障。它可用于阿尔茨海默病′（AD）病理学研究中的脑淀粉样蛋白β （Aβ）沉积的定量测定。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
N A Dezutter et al.
European journal of nuclear medicine, 26(11), 1392-1399 (1999-11-07)
Chrysamine G (CG), an analogue of Congo red, is known to bind in vitro to the beta-amyloid protein (Abeta 10-43) and to homogenates of several regions of the brain of Alzheimer's disease (AD) patients. We synthesised a conjugate of 2-(acetamido)-CG
D L Smith et al.
Neurobiology of disease, 8(6), 1017-1026 (2001-12-14)
Huntington's disease (HD) is a late onset neurodegenerative disorder caused by a CAG/polyglutamine (polyQ) repeat expansion. PolyQ aggregates can be detected in the nuclei and processes of neurons in HD patients and mouse models prior to the onset of symptoms.
Fusheng Yang et al.
The Journal of biological chemistry, 280(7), 5892-5901 (2004-12-14)
Alzheimer's disease (AD) involves amyloid beta (Abeta) accumulation, oxidative damage, and inflammation, and risk is reduced with increased antioxidant and anti-inflammatory consumption. The phenolic yellow curry pigment curcumin has potent anti-inflammatory and antioxidant activities and can suppress oxidative damage, inflammation
W E Klunk et al.
Neurobiology of aging, 16(4), 541-548 (1995-07-01)
Chrysamine-G (CG) is a carboxylic acid analogue of Congo red, a histologic dye which stains amyloid. CG binds to the beta-amyloid protein of Alzheimer's disease (AD) in vitro and partitions into the brain of normal mice. In this study, we
W E Klunk et al.
Life sciences, 63(20), 1807-1814 (1998-11-20)
Increasing evidence suggests that deposition of amyloid-beta (A beta) peptide leads to neurodegeneration in Alzheimer's disease. Congo red, a histologic dye that binds to amyloid has previously been shown to diminish the toxic effects of A beta in cell culture.
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