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C1119

Caroverine hydrochloride

Name: Caroverine hydrochloride
Brand: SIGMA

≥98% (HPLC), solid

别名:

1-[2-(Diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-2(1H)-quinoxalinone monohydrochloride

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₈ClN₃O₂

化学文摘社编号:

55750-05-5

分子量:

401.93

UNSPSC Code:

12352200

PubChem Substance ID:

329774856

MDL number:

MFCD01684929

Assay:

≥98% (HPLC)

Form:

solid

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属性

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Cl.CCN(CC)CCN1C(=O)C(Cc2ccc(OC)cc2)=Nc3ccccc13

InChI

1S/C22H27N3O2.ClH/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17;/h6-13H,4-5,14-16H2,1-3H3;1H

InChI key

JRNWTJUIMRLKBV-UHFFFAOYSA-N

说明

Biochem/physiol Actions

Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist.

Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist. Also, Caroverine hydrochloride is a class B calcium-channel-blocker, antiglutamatergic agent, and acts as an antioxidant when administered to lab animals.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

058K4601

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The quinoxaline derivative caroverine in the treatment of sensorineural smell disorders: a proof-of-concept study.

Christian Quint et al.

Acta oto-laryngologica, 122(8), 877-881 (2003-01-25)

The treatment of non-conductive olfactory disorders is to a large extent an unsolved problem. This proof-of-concept study focused on possible effects of the N-methyl-D-aspartate (NMDA) antagonist caroverine. Potential mechanisms for the hypothesized effect included reduced feedback inhibition in the olfactory

Caroverine, a multifunctional drug with antioxidant functions.

Hans Nohl et al.

BioFactors (Oxford, England), 19(1-2), 79-85 (2004-02-06)

Here we show that lipid peroxidation of liposomal membranes was suppressed in the presence of Caroverine, a spasmolytic drug used in some countries. In order to understand the mechanism of this antioxidant action of Caroverine we studied the interaction of

[Drug therapy for disturbances of smelling].

J Toth et al.

Laryngo- rhino- otologie, 83(2), 124-134 (2004-03-05)

Disorders of the sense of smell are frequent. This severely can affect the quality of live. Appropriate testing is needed to determine the nature of the patient's complaints. Following the pathogenesis, two main groups of smell disorders are discernable: The

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全球贸易项目编号

货号	GTIN
C1119-50MG	04061832081335
C1119-10MG	04061832081328