C1119
Caroverine hydrochloride
≥98% (HPLC), solid
别名:
1-[2-(Diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-2(1H)-quinoxalinone monohydrochloride
质量水平
方案
≥98% (HPLC)
表单
solid
溶解性
DMSO: >10 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
Cl.CCN(CC)CCN1C(=O)C(Cc2ccc(OC)cc2)=Nc3ccccc13
InChI
1S/C22H27N3O2.ClH/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17;/h6-13H,4-5,14-16H2,1-3H3;1H
InChI key
JRNWTJUIMRLKBV-UHFFFAOYSA-N
生化/生理作用
Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist.
Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist. Also, Caroverine hydrochloride is a class B calcium-channel-blocker, antiglutamatergic agent, and acts as an antioxidant when administered to lab animals.
特点和优势
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Maoli Duan et al.
Acta oto-laryngologica, 126(11), 1140-1147 (2006-10-20)
Physiological and morphological assessments indicated that low-dose and long-term caroverine delivery might be a new approach to protect against impulse noise-induced hearing loss. Although the exact mechanisms by which impulse noise causes hearing loss are still unclear, there is accumulating
S V Logvinov et al.
Neuroscience and behavioral physiology, 39(2), 217-221 (2009-01-14)
Changes in contacts between neurons in the internal reticular layer of the retina were studied in white rats 7 and 30 days after exposure to high-intensity light. Osmium preparations on day 7 demonstrated synapse destruction, predominantly of the "light" type
Different action of memantine and caroverine on glutamatergic transmission in the mammalian cochlea.
Elmar Oestreicher et al.
Advances in oto-rhino-laryngology, 59, 18-25 (2002-03-12)
Glutamate is the major transmitter candidate between inner hair cells and the afferent neurons of the mammalian cochlea. We investigated the action of memantine (1-amino-3,5-dimethyl-adamantane) and the quinoxaline derivative caroverine [1-diethylaminoethyl-3,8-(p-methoxybenzyl)-1,2-dihydro-quinoxaline-dione] on the glutamatergic transmission in the guinea pig cochlea
Caroverine in tinnitus treatment.
H Domeisen et al.
Acta oto-laryngologica, 118(4), 606-608 (1998-09-03)
Zhiqiang Chen et al.
Audiology & neuro-otology, 8(1), 49-56 (2003-02-05)
Caroverine, an N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, has been shown to protect the inner ear from excitotoxicity and to be effective in the treatment of cochlear synaptic tinnitus. Local administration of caroverine on the round window membrane (RWM) could
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