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C160

CGP-42112A

Name: CGP-42112A
Brand: SIGMA

synthetic, ≥95%, Angiotensin II receptor antagonist, solid

别名:

N_α-Nicotinoyl-Tyr-(N_α-Cbz-Arg)-Lys-His-Pro-Ile

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关于此项目

经验公式（希尔记法）:

C₅₂H₆₉N₁₃O₁₁

化学文摘社编号:

127060-75-7

分子量:

1052.18

NACRES:

NA.77

PubChem Substance ID:

24892424

UNSPSC Code:

12352200

MDL number:

MFCD00133611

Beilstein/REAXYS Number:

8184948

Assay:

≥95%

Form:

solid

Quality level:

200

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属性

产品名称

CGP-42112A, ≥95%, synthetic, solid

biological source

synthetic

Quality Level

200

assay

≥95%

form

solid

color

white

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)c5cccnc5)C(O)=O

InChI

1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1

InChI key

UXGNARZDONUMMK-LRMQDCNJSA-N

Gene Information

human ... AGTR2(186)
rat ... AGTR2(11609)

说明

Application

CGP-42112A has been used:

in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

Biochem/physiol Actions

CGP-42112A is a potent angiotensin II type 2 receptor (AT2R) agonist.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000511932

0000484342

0000492066

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Role for stress fiber contraction in surface tension development and stretch-activated channel regulation in C2C12 myoblasts.

Francesca Sbrana et al.

American journal of physiology. Cell physiology, 295(1), C160-C172 (2008-05-16)

Membrane-cytoskeleton interaction regulates transmembrane currents through stretch-activated channels (SACs); however, the mechanisms involved have not been tested in living cells. We combined atomic force microscopy, confocal immunofluorescence, and patch-clamp analysis to show that stress fibers (SFs) in C2C12 myoblasts behave

Angiotensin II type 2 receptor-stimulated activation of plasma prekallikrein and bradykinin release: role of SHP-1.

Liping Zhu et al.

American journal of physiology. Heart and circulatory physiology, 302(12), H2553-H2559 (2012-04-24)

ANG II type 2 receptors (AT(2)R) elicit cardioprotective effects in part by stimulating the release of kinins; however, the mechanism(s) responsible have not been fully explored. We demonstrated previously that overexpression of AT(2)R increased expression of prolylcarboxypeptidase (PRCP; a plasma

Angiotensin II type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats.

Claudia A McCarthy et al.

Hypertension (Dallas, Tex. : 1979), 60(6), 1531-1537 (2012-10-24)

We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor (AT(2)R) agonist is neuroprotective against a subsequent stroke independent of any changes in blood pressure. Therefore, in the current study, we have examined the potential neuroprotective effect

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全球贸易项目编号

货号	GTIN
C160-1MG	04061826152515
C160-5MG	04061833467770