Merck
CN
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文件

安全信息

C160

Sigma-Aldrich

CGP-42112A

≥95%, synthetic, solid

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别名:
Nα-Nicotinoyl-Tyr-(Nα-Cbz-Arg)-Lys-His-Pro-Ile
经验公式（希尔记法）:
C52H69N13O11
CAS号:
127060-75-7
分子量:
1052.18
Beilstein:
8184948
MDL编号:
MFCD00133611
PubChem化学物质编号:
24892424

生物来源

synthetic

质量水平

200

检测方案

≥95%

形式

solid

颜色

white

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)c5cccnc5)C(O)=O

InChI

1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1

InChI key

UXGNARZDONUMMK-LRMQDCNJSA-N

基因信息

human ... AGTR2(186)
rat ... AGTR2(11609)

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相关类别

Amino Acid Sequence

Tyr-Z-Arg-Lys-His-Pro-Ile

应用

CGP-42112A has been used:
  • in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
  • to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
  • as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

生化/生理作用

CGP-42112A is a potent angiotensin II type 2 receptor (AT2R) agonist.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

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Nancy J Hong et al.
Hypertension (Dallas, Tex. : 1979), 60(3), 765-769 (2012-07-11)
NO reduces NaCl absorption by thick ascending limbs (TALs) by inhibiting the Na/K/2Cl cotransporter (NKCC2). We have shown that NO-induced inhibition of Na transport is reduced in Dahl salt-sensitive rat (SS) TALs. Angiotensin II increases NO production in TALs via
Anu Vaajanen et al.
Investigative ophthalmology & visual science, 49(6), 2557-2562 (2008-01-29)
In the present study the effects of exogenous angiotensin II and its breakdown metabolite angiotensin (1-7) on the intraocular pressure (IOP) and on aqueous humor dynamics in normotensive rabbit eye were evaluated. Male New Zealand White rabbits with normal IOP
Rafael Rivas-Santisteban et al.
Journal of neuroinflammation, 17(1), 243-243 (2020-08-19)
The renin-angiotensin system (RAS) is altered in Parkinson's disease (PD), a disease due to substantia nigra neurodegeneration and whose dopamine-replacement therapy, using the precursor levodopa, leads to dyskinesias as the main side effect. Angiotensin AT1 and AT2 receptors, mainly known
L Laflamme et al.
The Journal of biological chemistry, 271(37), 22729-22735 (1996-09-13)
In the present study, 3-day treatment of nondifferentiated NG108-15 cells with 100 nM angiotensin II (Ang II) induces morphological differentiation of neuronal cells characterized by the outgrowth of neurites. These morphological changes are correlated with an increase in the level
R M A van de Wal et al.
Journal of cardiovascular pharmacology, 50(4), 372-379 (2007-12-01)
Several animal studies suggested that the angiotensin II type 2 (AT2) receptor subtype mediates vasodilation, yet the results in human arteries are less well described and more inconsistent. Therefore, we evaluated the role of the AT2 receptor stimulation on the
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