生物来源
bovine heart
质量水平
方案
≥97% (TLC)
表单
liquid
包装
glass bottle of
浓度
4.7-5.3 mg/mL in ethanol
颜色
colorless to yellow
应用
general analytical
lipidomics
metabolomics
官能团
phospholipid
脂质类型
phosphoglycerides
运输
dry ice
储存温度
−20°C
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一般描述
心磷脂(CL)是二聚体结构的复杂脂质。含4条酰基链和2个磷脂酰基，磷脂酰基与甘油骨架相连。心磷脂成分约占线粒体内膜的15-20%。
心磷脂是一种独特的磷脂，广泛存在于线粒体内膜中。这种特殊的位置使心磷脂对线粒体的结构和功能造成重要影响。心磷脂含量、结构和位置的差异会导致线粒体活性受损，从而产生各种疾病，如癌症、神经功能失调、心血管问题和代谢疾病。由于心磷脂在线粒体功能中起到关键作用，它为生物标志物开发带来巨大潜力，并在心血管、神经科学、癌症、糖尿病和代谢组学研究中得到广泛应用。
应用
心磷脂溶液（来自牛心）已用于：
- 包被Corning酶免疫/放射免疫分析96孔板，用于基于酶联免疫吸附法(ELISA)的心磷脂结合试验
- 与磷脂酰甘油共同用于脂质分析，通过放射性标记脂质共迁移来鉴定磷脂酰甘油和心磷脂
- 包被ELISA板用于磷脂抗体(aPL)检测
生化/生理作用
心磷脂(CL)在线粒体的生物发生、融合和裂变、呼吸和蛋白输入中起着至关重要的作用。在线粒体外参与细胞壁的生物发生、衰老、液泡内稳态、细胞周期和凋亡等细胞过程。心磷脂也参与心脏功能、自噬/线粒体自噬和蛋白激酶C(PKC)途径。
心磷脂是一种线粒体磷脂，以低浓度分布于哺乳动物组织中。 常为膜成分，可抑制纤连蛋白、玻连蛋白和Ⅰ型胶原蛋白粘附细胞。
特点和优势
- 适用于多种研究应用的优质分子
- 常用于代谢组学和生物化学研究
外形
大约为5mg/ml溶于乙醇。
制备说明
用心磷脂盐制备
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
55.4 °F - closed cup
闪点(°C)
13 °C - closed cup
法规信息
危险化学品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Keun Young Hwang et al.
Journal of virology, 90(1), 506-520 (2015-10-30)
Mitochondrial lipid raft-like microdomains, experimentally also termed mitochondrial detergent-resistant membrane fractions (mDRM), play a role as platforms for recruiting signaling molecules involved in antiviral responses such as apoptosis and innate immunity. Viruses can modulate mitochondrial functions for their own survival
Hervé Roy et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(12), 4667-4672 (2008-02-29)
Multiple peptide resistance (MprF) virulence factors control cellular permeability to cationic antibiotics by aminoacylating inner membrane lipids. It has been shown previously that one class of MprF can use Lys-tRNA(Lys) to modify phosphatidylglycerol (PG), but the mechanism of recognition and
Michael S Lee et al.
Cells, 9(4) (2020-04-25)
Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin's lymphoma. Despite being responsive to combination chemotherapy, median survival remains around 5 years due to high rates of relapse. Sphingolipid metabolism regulates MCL survival and proliferation and we found that
Denong Wang et al.
Drug development research, 75(3), 172-188 (2014-03-22)
Using an integrated antigen microarray approach, we observed epitope-spreading of autoantibody responses to a variety of antigenic structures in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and in the serum of mice with experimental autoimmune encephalomyelitis (EAE).
Lidia Lancellotti et al.
Bioelectrochemistry (Amsterdam, Netherlands), 136, 107628-107628 (2020-08-17)
The Met80Ala and Met80Ala/Tyr67Ala variants of S. cerevisiae iso-1 cytochrome c (ycc) and their adducts with cardiolipin immobilized onto a gold electrode coated with a hydrophobic self-assembled monolayer (SAM) of decane-1-thiol were studied through cyclic voltammetry and surface-enhanced resonance Raman
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