C1688
单克隆抗 C 反应蛋白 小鼠抗
clone CRP-8, purified from hybridoma cell culture
别名:
抗 CRP
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关于此项目
Conjugate:
unconjugated
Clone:
CRP-8, monoclonal
Application:
DB, ELISA (i), WB
Citations:
29
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
CRP-8, monoclonal
mol wt
antigen 24 kDa
contains
15 mM sodium azide
species reactivity
human
technique(s)
dot blot: suitable, indirect ELISA: 1:40,000-80,000, western blot: 1:200-400
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CRP(1401)
General description
C反应蛋白(CRP)是正五聚蛋白家族成员之一，由肝脏合成。又名PTX1。CRP基因定位于人染色体1q23.2。
Immunogen
人 C 反应蛋白。
Application
- 它可用于免疫印迹试验，以鉴别单体 CRP。
- 时间分辨荧光测定法。
小鼠产生的单克隆抗 C 反应蛋白抗体适用于以下情况：
- 斑点印迹分析
- 工作稀释度为 1:40,000 的间接 ELISA
- 1:200 工作稀释液的免疫印迹法
Biochem/physiol Actions
该抗体识别位于变性和还原 CRP 的 24 kDa 亚单位上的表位。与人血清淀粉样 P 成分 (SAP)、人结合珠蛋白、人 α1-酸性糖蛋白、人 IgG 和来自 鲎试剂的 CRP 不反应。
C反应蛋白(CRP)发挥关键的清除和代谢作用，还与防御机制有关。可通过结合含有磷酰胆碱(PC)的钙依赖性外源和自体分子，激活补体途径。它具有致病作用，可作为肝细胞癌(HCC)患者实用的预后指标。 CRP对于急性肾盂肾炎(pyelonephritis)的诊断价值高于下尿路感染，因此有助于区分上和下尿路感染。它被视为心血管疾病风险预测的最佳指标。
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或人类或动物应用。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
动植物来源生物产品
常规特殊物品
常规特殊物品
此项目有
Travis W Hein et al.
Circulation research, 114(1), 92-100 (2013-10-22)
Studies in cultured endothelium implicate that lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) or Fcγ receptor II (CD32) contributes to the proatherogenic effects of C-reactive protein (CRP). However, the identity of the receptors linking to deleterious actions of CRP in vasomotor
Robert D Williams et al.
Frontiers in immunology, 11, 115-115 (2020-03-03)
A monomeric form of C-reactive protein (CRP) which precipitates with cell wall pneumococcal C polysaccharide (CWPS) and retains the ability to reversibly bind to its ligand phosphocholine has been produced through urea-induced dissociation at an optimized concentration of 3 M
Rui-Ying Xu et al.
BMC urology, 14, 45-45 (2014-06-03)
Urinary infections are a common type of pediatric disease, and their treatment and prognosis are closely correlated with infection location. Common clinical manifestations and laboratory tests are insufficient to differentiate between acute pyelonephritis and lower urinary tract infection. This study
Lin Zhang et al.
Frontiers in immunology, 9, 511-511 (2018-03-30)
Native C-reactive protein (nCRP) is a non-specific marker of inflammation being claimed as a bystander in several chronic disorders. Accumulating evidence indicates that nCRP dissociates to and acts primarily as the monomeric conformation (mCRP) at inflammatory loci. This suggests that
Eun Na Kim et al.
Journal of chest surgery, 54(1), 9-16 (2021-03-27)
The deposition of monomeric C-reactive protein (mCRP) in the myocardium aggravates ischemia-reperfusion injury (IRI) and myocardial infarction. Ischemic preconditioning (IPC) is known to protect the myocardium against IRI. We evaluated the effects of IPC on myocardium upon which mCRP had
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