产品名称
单克隆抗 C 反应蛋白 小鼠抗, clone CRP-8, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
CRP-8, monoclonal
mol wt
antigen 24 kDa
contains
15 mM sodium azide
species reactivity
human
technique(s)
dot blot: suitable
indirect ELISA: 1:40,000-80,000
western blot: 1:200-400
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CRP(1401)
Biochem/physiol Actions
该抗体识别位于变性和还原 CRP 的 24 kDa 亚单位上的表位。与人血清淀粉样 P 成分 (SAP)、人结合珠蛋白、人 α1-酸性糖蛋白、人 IgG 和来自 鲎试剂的 CRP 不反应。
C反应蛋白(CRP)发挥关键的清除和代谢作用，还与防御机制有关。可通过结合含有磷酰胆碱(PC)的钙依赖性外源和自体分子，激活补体途径。它具有致病作用，可作为肝细胞癌(HCC)患者实用的预后指标。 CRP对于急性肾盂肾炎(pyelonephritis)的诊断价值高于下尿路感染，因此有助于区分上和下尿路感染。它被视为心血管疾病风险预测的最佳指标。
Application
- 它可用于免疫印迹试验，以鉴别单体 CRP。
- 时间分辨荧光测定法。
小鼠产生的单克隆抗 C 反应蛋白抗体适用于以下情况：
- 斑点印迹分析
- 工作稀释度为 1:40,000 的间接 ELISA
- 1:200 工作稀释液的免疫印迹法
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或人类或动物应用。
General description
C反应蛋白(CRP)是正五聚蛋白家族成员之一，由肝脏合成。又名PTX1。CRP基因定位于人染色体1q23.2。
Immunogen
人 C 反应蛋白。
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo.
Sato A, et al.
European Journal of Pharmacology, 745, 46-51 (2014)
Birgit Fendl et al.
Scientific reports, 11(1), 6996-6996 (2021-03-28)
There is increasing evidence that C-reactive protein (CRP) can mediate inflammatory reactions following the transformation of functionally inert pentameric CRP (pCRP) into its structural isoform pCRP* and into monomeric CRP (mCRP). This conversion can occur on the membranes of apoptotic
The effect of C-reactive protein deposition on myocardium with ischaemia-reperfusion injury in rats.
Se Jin Oh et al.
Interactive cardiovascular and thoracic surgery, 25(2), 260-267 (2017-05-06)
We evaluated the effect of monomeric C-reactive protein (CRP) deposition on areas at risk (AAR) of myocardium with ischaemia-reperfusion injury. Myocardial ischaemia-reperfusion injury model was produced by ligation of the left anterior descending coronary artery for 45 min followed by 45 min
Aleksandra N Klisic et al.
Laboratory medicine, 45(1), 12-16 (2014-04-12)
Although C-reactive protein (CRP) is among the best cardiovascular disease risk predictors, data regarding the association of CRP and menopause are controversial. In this study, we measured CRP by a high-sensitivity method (hsCRP), cholesterol, lipoproteins, and triglycerides in normal and
Akiyoshi Kinoshita et al.
Oncology, 86(5-6), 308-317 (2014-06-14)
C-reactive protein (CRP) is a practical prognostic marker in patients with hepatocellular carcinoma (HCC). We investigated the prognostic value of adding the CRP level to other validated staging systems (Cancer Liver Italian Program, Japan Integrated Staging, Barcelona Clinic Liver Cancer
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