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C197

8-(3-Chlorostyryl)caffeine

Name: 8-(3-Chlorostyryl)caffeine
Brand: SIGMA

≥98% (HPLC), solid

别名:

1,3,7-Trimethyl-8-(3-chlorostyryl)xanthine, CSC

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₅ClN₄O₂

化学文摘社编号:

147700-11-6

分子量:

330.77

NACRES:

NA.77

PubChem Substance ID:

24277703

UNSPSC Code:

12352200

MDL number:

MFCD00210188

Assay:

≥98% (HPLC)

Form:

solid

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属性

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >5 mg/mL

storage temp.

−20°C

SMILES string

[H]\C(=C(\[H])c1nc2C(=O)N(C)C(=O)N(C)c2n1C)c3cccc(Cl)c3

InChI

1S/C16H15ClN4O2/c1-19-12(8-7-10-5-4-6-11(17)9-10)18-13-14(19)20(2)16(23)21(3)15(13)22/h4-9H,1-3H3/b8-7+

InChI key

MHYRUZOJQQLLQS-BQYQJAHWSA-N

Gene Information

human ... ADORA2A(135)
mouse ... Maob(109731)
rat ... Adora1(29290), Adora2a(25369)

说明

Application

8-(3-Chlorostyryl)caffeine has been used as an adenosine A_2A receptor antagonist:

to study its effects on levodopa (L-DOPA)-induced dopamine (DA) release in rat striatum
to study its effect on the nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) activity in macrophages
to determine its effects on human umbilical vein endothelial cells (HUVECs)

Biochem/physiol Actions

8-(3-Chlorostyryl)caffeine is a selective adenosine A_2A receptor antagonist and monoamine oxidase B (MAO B) inhibitor.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Photosensitive, store in the dark

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000535682

0000531494