质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: >5 mg/mL
储存温度
−20°C
SMILES字符串
[H]\C(=C(\[H])c1nc2C(=O)N(C)C(=O)N(C)c2n1C)c3cccc(Cl)c3
InChI
1S/C16H15ClN4O2/c1-19-12(8-7-10-5-4-6-11(17)9-10)18-13-14(19)20(2)16(23)21(3)15(13)22/h4-9H,1-3H3/b8-7+
InChI key
MHYRUZOJQQLLQS-BQYQJAHWSA-N
基因信息
human ... ADORA2A(135)
mouse ... Maob(109731)
rat ... Adora1(29290), Adora2a(25369)
应用
8-(3-Chlorostyryl)caffeine has been used as an adenosine A2A receptor antagonist:
- to study its effects on levodopa (L-DOPA)-induced dopamine (DA) release in rat striatum
- to study its effect on the nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) activity in macrophages
- to determine its effects on human umbilical vein endothelial cells (HUVECs)
生化/生理作用
8-(3-Chlorostyryl)caffeine is a selective adenosine A2A receptor antagonist and monoamine oxidase B (MAO B) inhibitor.
特点和优势
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
注意
Photosensitive, store in the dark
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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