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C2020

α-氰基-4-羟基肉桂酸

Name: &#945;-氰基-4-羟基肉桂酸
Brand: SIGMA

≥98% (TLC), powder, monocarboxylic acid transport inhibitor

别名:

α-CCA, α-CHCA, α-氰基, 4-HCCA, ACCA

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关于此项目

线性分子式:

HOC₆H₄CH=C(CN)CO₂H

化学文摘社编号:

28166-41-8

分子量:

189.17

NACRES:

NA.77

PubChem Substance ID:

24892459

UNSPSC Code:

12352106

EC Number:

248-879-1

MDL number:

MFCD00004204

Beilstein/REAXYS Number:

3271427

Assay:

≥98% (TLC)

Form:

powder

Quality level:

300

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产品名称

α-氰基-4-羟基肉桂酸, ≥98% (TLC), powder

Quality Level

300

assay

≥98% (TLC)

form

powder

color

yellow

mp

245-250 °C (lit.)

solubility

H₂O: slightly soluble, methanol: water: soluble, polar organic solvents: soluble

storage temp.

2-8°C

SMILES string

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

InChI key

AFVLVVWMAFSXCK-VMPITWQZSA-N

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Application

α5-氰基-4-羟基肉桂酸是用于基质辅助激光解吸/电离飞行时间（MALDI-TOF）质谱的一种有用的疏水性基质溶液。将其用作基质溶液，成功地分析了抗生素、肽核酸（一类新的DNA模拟物）和质量高达66,000 Da的蛋白。

α5-氰基-4-羟基肉桂酸已被用于阻断单羧酸盐转运蛋白。

Biochem/physiol Actions

α-氰基-4-羟基肉桂酸可充当一元羧酸转运的特异性抑制剂，包括乳酸和丙酮酸的转运。据报道，其还可阻断β-细胞顶端阴离子交换（IC₅₀ 为2.4 mM）。

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1B

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate. In the present study, we used double-barrelled pH-sensitive microelectrodes to investigate the link between lactate

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Biotechnology and bioengineering, 103(2), 402-412 (2009-03-07)

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Eliasen MM, et al.

Frontiers in Bioscience, 11, 3199-3211 (2006)

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Lev-Vachnish Y, et al.

Frontiers in Neuroscience, 13 (2019)

Glucose catabolism in African trypanosomes. Evidence that the terminal step is catalyzed by a pyruvate transporter capable of facilitating uptake of toxic analogs.

J P Barnard et al.

The Journal of biological chemistry, 268(5), 3654-3661 (1993-02-15)

The protozoan parasite Trypanosoma brucei derives its metabolic energy exclusively from a unique type of glycolysis in which pyruvate derived from glucose catabolism is released into the host bloodstream. In this study, this terminal metabolic step has been examined in

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本页面介绍了一篇有关瓦博格效应的文章，以及其如何能够在正常氧气水平下，增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明，癌细胞显示出对糖酵解的依赖性增加，以满足他们的能量需求，无论是否有充足的氧气存在。

全球贸易项目编号

货号	GTIN
C2020-10G	04061833475003
C2020-25G	04061833475010

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