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Merck
CN

C2020

Sigma-Aldrich

α-氰基-4-羟基肉桂酸

≥98% (TLC), powder, monocarboxylic acid transport inhibitor

别名:

α-CCA, α-CHCA, α-氰基, 4-HCCA, ACCA

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关于此项目

线性分子式:
HOC6H4CH=C(CN)CO2H
化学文摘社编号:
28166-41-8
分子量:
189.17
Beilstein:
3271427
EC 号:
248-879-1
MDL编号:
MFCD00004204
UNSPSC代码:
12352106
PubChem化学物质编号:
24892459
NACRES:
NA.77

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产品名称

α-氰基-4-羟基肉桂酸, ≥98% (TLC), powder

质量水平

300

方案

≥98% (TLC)

表单

powder

颜色

yellow

mp

245-250 °C (lit.)

溶解性

H2O: slightly soluble
methanol: water: soluble
polar organic solvents: soluble

储存温度

2-8°C

SMILES字符串

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

InChI key

AFVLVVWMAFSXCK-VMPITWQZSA-N

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相关类别

应用

α5-氰基-4-羟基肉桂酸已被用于阻断单羧酸盐转运蛋白。
α5-氰基-4-羟基肉桂酸是用于基质辅助激光解吸/电离飞行时间（MALDI-TOF）质谱的一种有用的疏水性基质溶液。将其用作基质溶液，成功地分析了抗生素、肽核酸（一类新的DNA模拟物）和质量高达66,000 Da的蛋白。

生化/生理作用

α-氰基-4-羟基肉桂酸可充当一元羧酸转运的特异性抑制剂，包括乳酸和丙酮酸的转运。据报道，其还可阻断β-细胞顶端阴离子交换（IC50 为2.4 mM）。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H317

危险分类

Skin Sens. 1B

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCR5823
MKCN9036
MKCK1270
MKCJ2237
MKCH2027

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What can be used for solublization of α-Cyano-4-hydroxycinnamic acid?

    α-Cyano-4-hydroxycinnamic acid (α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA) is soluble in methanol (up to 50 mg/ml). It is also soluble at 10 mg/ml using 50% acetonitrile in 0.05% TFA for MALDI-MS. The acetonitrile concentration can be adjusted for individual preferences.For biological applications, it has been solubilized at 100 mM in DMSO or 50 mM in ethanol.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Adaptive cellular mechanisms in response to Glutamine-starvation
Eliasen MM, et al.
Frontiers in Bioscience, 11, 3199-3211 (2006)
U Schneider et al.
Neuroscience, 53(4), 1153-1162 (1993-04-01)
Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate. In the present study, we used double-barrelled pH-sensitive microelectrodes to investigate the link between lactate
Elizabeth Csaszar et al.
Biotechnology and bioengineering, 103(2), 402-412 (2009-03-07)
An automated delivery system for cell culture applications would permit studying more complex culture strategies and simplify measures taken to expose cells to unstable molecules. We are interested in understanding how intracellular TAT-HOXB4 protein concentration affects hematopoietic stem cell (HSC)
C Emmons
The American journal of physiology, 276(4 Pt 2), F635-F643 (1999-04-13)
To functionally characterize transport properties of the apical anion exchanger of rabbit beta-intercalated cells, the mean change in anion exchange activity, dpHi/dt (where pHi is intracellular pH), was measured in response to lumen Cl- replacement with gluconate in perfused cortical
Y C Ling et al.
Rapid communications in mass spectrometry : RCM, 12(6), 317-327 (1998-04-16)
Comparative studies of the matrix-assisted laser desorption/ionization (MALDI) of 30 antibiotics were made using alpha-cyano-4-hydroxycinnamic acid (HCCA), 2,5-dihydroxybenzoic acid (DHB), 5,10,15,20-tetrakis(4-hydroxyphenyl)-21H,23H-porphyrin and meso-tetra(N-methyl-4-pyridyl)porphyrin matrices. Most antibiotics generated intense protonated molecules in HCCA and DHB matrices, and sodium or potassium adduct
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