C2063
Monoclonal Anti-CD71 (Transferrin Receptor) antibody produced in mouse
clone DF 1513, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
DF 1513, monoclonal
form
buffered aqueous solution
mol wt
antigen 90-95 kDa
species reactivity
human
technique(s)
flow cytometry: 5 μL using 1 × 106 cells
isotype
IgG1
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... TFRC(7037)
General description
CD71 (90-95 kDa) is a two-disulfide-bonded homodimeric glycoprotein (180 kDa) present on activated T and B cells, a subset of reticulocytes and on many activated proliferating cells. The expression of transferrin receptor expression on resting mature white blood cells is very low. However, this is up-regulated upon activation, reflecting the iron dependency of proliferation. CD71 is also found on macrophages, osteoblasts, germ cells, brain capillary endothelium and in virtually all permanent cell lines. This receptor is broadly distributed in carcinomas, sarcomas, leukemias and lymphomas.
Immunogen
KG1 acute myeloid leukemia cell line
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunocytochemistry (1 paper)
Biochem/physiol Actions
Recognizes the CD71 human cell surface transferrin receptor. Human CD71 antibody is useful for flow cytometric and immunohistochemical studies of transformed cell lines, mitogen or antigen stimulated lymphocytes, erythropoietic cells, malignant tumors and germ cells.
4th Workshop: code no. M 84.
4th Workshop: code no. M 84.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
法规信息
新产品
此项目有
Daniel P Ferris et al.
Small (Weinheim an der Bergstrasse, Germany), 7(13), 1816-1826 (2011-05-20)
Synthetic methodologies integrating hydrophobic drug delivery and biomolecular targeting with mesoporous silica nanoparticles are described. Transferrin and cyclic-RGD peptides are covalently attached to the nanoparticles utilizing different techniques and provide selectivity between primary and metastatic cancer cells. The increase in
Olga C Rodriguez et al.
Journal of cell science, 115(Pt 5), 991-1004 (2002-03-01)
Class V myosins are one of the most ancient and widely distributed groups of the myosin superfamily and are hypothesized to function as motors for actin-dependent organelle transport. We report the discovery and initial characterization of a novel member of
Zahra Nikoozad et al.
Iranian journal of basic medical sciences, 17(1), 27-33 (2014-03-05)
Stem cell therapy is believed to be as a promising treatment strategy for tissue repair and regeneration. The plasticity specification of the adult stem cells, such as MSCs, has enabled that these cells to be used in the treatment of
Fatemeh Moradi et al.
Cell journal, 13(4), 243-250 (2012-01-01)
It has been reported that rat bone marrow stromal cells (BMSCs) can be spontaneously differentiated into neural-like cells without any supplemental growth factors and/or chemical treatment after long-term culture.This study aims to determineWhether, growth factors secreted by MSCs could induce
Simon H Jiang et al.
Nature communications, 10(1), 2201-2201 (2019-05-19)
Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease. It is thought that many common variant gene loci of weak effect act additively to predispose to common autoimmune diseases, while the contribution of rare variants remains unclear. Here we
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