C2615
色原烷醇293B
≥98% (HPLC), potassium channel protein (KvLQT1) inhibitor, powder
别名:
反式-N-[6-氰基-3,4-二氢-3-羟基-2,2-二甲基-2H-1-苯并吡喃-4-基]-N-甲基-乙磺酰胺
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关于此项目
经验公式（希尔记法）:
C15H20N2O4S
化学文摘社编号:
分子量:
324.40
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
色原烷醇293B, ≥98% (HPLC), powder
SMILES string
CCS(=O)(=O)N(C)[C@@H]1[C@@H](O)C(C)(C)Oc2ccc(cc12)C#N
InChI
1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1
InChI key
HVSJHHXUORMCGK-UONOGXRCSA-N
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: 18 mg/mL
storage temp.
−20°C
Quality Level
Application
色原烷醇293B已用于抑制人上皮细胞系中钙和环腺苷一磷酸（cAMP）激活的钾通道。色原烷醇293B已用于心肌细胞的膜片钳电生理学研究。
Biochem/physiol Actions
通过KCNQ1通道阻断慢延迟整流器K+流
General description
色原烷醇293B对映体是钾通道蛋白（KvLQT1）的一种有效抑制剂。在人心房肌细胞中，色原烷醇293B可抑制复极钾电流。色原烷醇293B可通过调节钾电压门控通道（KCNQ1）而改善胰腺中葡萄糖刺激的胰岛素分泌（GSIS）。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Effects of chromanol 293B on transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes
Du XL, et al.
Journal of Molecular and Cellular Cardiology, 35(3), 293-300 (2003)
Chromanol 293B, an inhibitor of KCNQ1 channels, enhances glucose-stimulated insulin secretion and increases glucagon-like peptide-1 level in mice
Liu L, et al.
Islets, 6(4), e962386-e962386 (2014)
C Lengyel et al.
British journal of pharmacology, 132(1), 101-110 (2001-01-13)
1. The effects of I(Ks) block by chromanol 293B and L-735,821 on rabbit QT-interval, action potential duration (APD), and membrane current were compared to those of E-4031, a recognized I(Kr) blocker. Measurements were made in rabbit Langendorff-perfused whole hearts, isolated
Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels
Yang IC, et al.
Journal of Pharmacology and Experimental Therapeutics, 294(3), 955-962 (2000)
A Varro et al.
The Journal of physiology, 523 Pt 1, 67-81 (2000-02-16)
1. The relative contributions of the rapid and slow components of the delayed rectifier potassium current (IKr and IKs, respectively) to dog cardiac action potential configuration were compared in ventricular myocytes and in multicellular right ventricular papillary muscle and Purkinje
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