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Merck
CN

C2643

辅酶 A，氧化 锂盐

≥85%

别名:

CoA-S-S-CoA

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关于此项目

经验公式（希尔记法）:
C42H70N14O32P6S2 · xLi+
化学文摘社编号:
31664-36-5
分子量:
1533.05 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
24892510
NACRES:
NA.51
Assay:
≥85%
Form:
solid

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产品名称

辅酶 A，氧化 锂盐, ≥85%

SMILES string

[P](=O)(O[P](=O)(OCC([C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(CO[P](=O)(O[P](=O)(OC[C@H]4O[C@H]([C@@H]([C@@H]4O[P](=O)(O)O)O)[n]5c6ncnc(c6nc5)N)O)O)(C)C)(C)C)O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O[P](=O)(O)O)O)[n]2c3ncnc(c3nc2)N)O

InChI

1S/C42H70N14O32P6S2/c1-41(2,15-81-93(75,76)87-91(71,72)79-13-21-29(85-89(65,66)67)27(59)39(83-21)55-19-53-25-33(43)49-17-51-35(25)55)31(61)37(63)47-7-5-23(57)45-9-11-95-96-12-10-46-24(58)6-8-48-38(64)32(62)42(3,4)16-82-94(77,78)88-92(73,74)80-14-22-30(86-90(68,69)70)28(60)40(84-22)56-20-54-26-34(44)50-18-52-36(26)56/h17-22,27-32,39-40,59-62H,5-16H2,1-4H3,(H,45,57)(H,46,58)(H,47,63)(H,48,64)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H2,43,49,51)(H2,44,50,52)(H2,65,66,67)(H2,68,69,70)/t21-,22-,27-,28-,29-,30-,31+,32+,39-,40-/m1/s1

InChI key

YAISMNQCMHVVLO-ODFVJXNFSA-N

assay

≥85%

form

solid

storage temp.

−20°C

Quality Level

200

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相关类别

Application

辅酶 A 氧化锂盐已用于制备辅酶 A 过硫化物 (CoASSH) 标准品，以串联质谱法定量金黄色葡萄球菌菌株中的CoASSH。

Biochem/physiol Actions

辅酶 A (CoA) 在三羧酸循环和脂肪酸代谢等多种生化反应中充当酰基载体和羰基活化剂。它充当多种酶的辅助因子，参与多种中间代谢反应。CoA 含有硫醇基团，能够参与多种生化反应。氧化的CoA可用于研究在体内再生还原CoA的还原系统（CoA二硫键还原酶（CoADR）系统）。此外，氧化的CoA可用于研究该分子在体内的独特功能。

General description

辅酶 A (CoA) 是所有生物体普遍存在的一种辅助因子，通过半胱氨酸、泛酸（维生素 B5）和三磷酸腺苷 (ATP) 的酶促结合合成。

signalword

Danger

pictograms

Corrosion
GHS05

hcodes

H315,H318

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2

存储类别

4.1B - Flammable solid hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000368676
0000368676
SLCM7634
SLBF5065V
SLBF5065

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Charles S Hummel et al.
FEMS microbiology letters, 252(2), 229-234 (2005-10-11)
Physiologically significant levels of intracellular coenzyme A were identified in Pyrococcus furiosus, Thermococcus litoralis, and Sulfolobus solfataricus, suggesting a role for CoA as an important low molecular mass thiol in the thermophilic Archaea. In P. furiosus, cells grown in the
V M Avakumov et al.
Eksperimental'naia i klinicheskaia farmakologiia, 56(1), 42-44 (1993-01-01)
Coenzyme A disulfide (CoA disulfide) was pharmacologically studied. It has been found to normalize lipid and carbohydrate metabolism when given in a dose of 2 mg/kg, i.m., in diverse liver dysfunctions. It possesses an antihypoxic action under hemic and histotoxic
S B delCardayre et al.
The Journal of biological chemistry, 273(10), 5744-5751 (1998-04-16)
The human pathogen Staphylococcus aureus does not utilize the glutathione thiol/disulfide redox system employed by eukaryotes and many bacteria. Instead, this organism produces CoA as its major low molecular weight thiol. We report the identification and purification of the disulfide
H F Gilbert et al.
The Journal of biological chemistry, 256(4), 1782-1785 (1981-02-25)
The time-dependent inactivation of hydroxymethylglutaryl-CoA reductase from yeast by solutions of hydroxymethylglutaryl-CoA and CoASH is due to the rapid inactivation of the enzyme by oxidized CoA (CoA disulfide) present at trace levels in solutions of hydroxymethylglutaryl-CoA and CoASH. Solutions of
Julie A Boylan et al.
Molecular microbiology, 59(2), 475-486 (2006-01-05)
The cellular responses of Borrelia burgdorferiTo reactive oxygen species (ROS) encountered during the different stages of its infective cycle are poorly understood. Few enzymes responsible for protecting proteins, DNA/RNA and lipids from damage by ROS have been identified and characterized.
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