C3237
Anti-Caveolin-1 antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-Caveolin-1, Anti-VIP21
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IF, WB
Citations:
19
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 22 kDa
species reactivity
human, rat, mouse
enhanced validation
independent
Learn more about Antibody Enhanced Validation
technique(s)
indirect immunofluorescence: 1:500 using mouse fibroblast NIH3T3 cell line, microarray: suitable, western blot: 1:2,000 using whole cell extract of the human umbilical vein endothelial HUVEC cell line and the rat fibroblast Rat-1 cell line
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)
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General description
Anti-Caveolin-1 is developed in rabbit using a synthetic peptide corresponding to a region at the N-terminus of human caveolin-1 conjugated to keyhole limpet hemocyanin (KLH) as immunogen. Caveolin-1 (CAV1) is a multifunctional scaffolding protein, that has three exons. It is located on chromosome 7q31.
Caveolin, a 20-24-kDa integral transmembrane protein, has been identified as a principal component of caveolae membranes. Caveolin (also termed VIP21) exists in several isoforms termed caveolin-1, caveolin-2 and caveolin-3. Caveolin-1 (20-22 kDa) can exist as two isoforms, caveolin-1α and -1β due to alternative splicing of the mRNA.
Immunogen
synthetic peptide corresponding to a region at the N-terminus of human caveolin-1 (amino acids 2-20).
Application
Anti-Caveolin-1 antibody produced in rabbit has been used in:
- indirect immunofluorescence
- in confocal microscopy
- western blotting
Biochem/physiol Actions
Caveolin family members function as scaffolding proteins to organize and concentrate specific lipids such as cholesterol and glycosylphosphatidylinositol (GPI) and lipid modified signaling molecules within caveolae membranes. Staining of caveolin-1 in immunoblotting is specifically inhibited with caveolin-1 immunizing peptide (human, amino acids 2-20).†
Caveolin-1 is expected to play a major role in the growth and evolution of cancer. It participates in glucose metabolism. It may also participate in angiogenesis. Cav-1 helps to control the expression of glucose transporters.
The sequence is highly conserved in many species, e.g., identical in rat, mouse, bovine, and dog caveolin-1. The sequence is not found in caveolin-2 or caveolin-3.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Jennifer van der Horst et al.
The Journal of general physiology, 153(3) (2021-02-04)
The dynein motor protein transports proteins away from the cell membrane along the microtubule network. Recently, we found the microtubule network was important for regulating the membrane abundance of voltage-gated Kv7.4 potassium channels in vascular smooth muscle. Here, we aimed
Akari Kondo-Kawai et al.
Journal of clinical biochemistry and nutrition, 69(1), 28-36 (2021-08-12)
Caveolin-1 is a major protein of the caveolae structure in vascular endothelial cell membrane. Phosphorylation of caveolin-1 is one of the initial events leading to exacerbation of vascular permeability caused by oxidative stress. Although quercetin is known to be an
Co-expression of MG29 and Ryanodine Receptor Leads to Apoptotic Cell Death EFFECT MEDIATED BY INTRACELLULAR Ca2+ RELEASE
Pan Z, et al.
The Journal of Biological Chemistry, 279(19), 19387-19390 (2004)
Rac1 participates in thermally induced alterations of the cytoskeleton, cell morphology and lipid rafts, and regulates the expression of heat shock proteins in B16F10 melanoma cells
Gungor B, et al.
Testing, 9(2), e89136-e89136 (2014)
Cholesterol-sensitive modulation of transcytosis
Leyt J, et al.
Molecular Biology of the Cell, 18(6), 2057-2071 (2007)
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