C3285
Complement C6 来源于人类血清
80% (SDS-PAGE), >300,000 C6H50 units/mg protein
一般描述
Complement C6 is one of five complement cascade proteins that are incorporated into the lytic terminal complement complex. It is over 33% homologous with C7, including all 56 cysteine residues; C6 and C7 share the arrangement of LDL-receptor class A and B modules, the thrombospondin type I module at the C-terminus, and the two short consensus repeat modules.
The mature protein consists of 913 amino acid residues preceded by a 21-residue signal sequence.
The mature protein consists of 913 amino acid residues preceded by a 21-residue signal sequence.
应用
Complement C6 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). It has been shown that complement C6 and the MAC are crucial for the development of arthritis in osteoarthritis and gouty arthritis. This could serve as a therapeutic target area for suppression of joint inflammation.
分析说明
Functionally active by a sensitive hemolytic assay.
其他说明
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
免责声明
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
T John et al.
Histology and histopathology, 22(7), 781-790 (2007-04-25)
The limited ability of articular cartilage to recover from injury, remains an unsolved clinical challenge in orthopaedic surgery. Persistent injury of the articular surface can lead to the development of posttraumatic osteoarthritis. The local inflammatory response contributes to the pathogenesis
Nicole Tramontini et al.
Arthritis and rheumatism, 50(8), 2633-2639 (2004-08-31)
Monosodium urate monohydrate (MSU) crystals promote gouty inflammation that is critically mediated by neutrophil recruitment and activation. Interleukin-8 (IL-8) and closely related chemokines are major neutrophil chemotaxins in experimental gout. But MSU crystals also activate the classical and alternative pathways
Identification of a central role for complement in osteoarthritis.
Identification of a central role for complement in osteoarthritis.
Nature Materials, 17, 1674-1979 (2011)
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