C3285
Complement C6 来源于人类血清
80% (SDS-PAGE), >300,000 C6H50 units/mg protein
General description
Complement C6 is one of five complement cascade proteins that are incorporated into the lytic terminal complement complex. It is over 33% homologous with C7, including all 56 cysteine residues; C6 and C7 share the arrangement of LDL-receptor class A and B modules, the thrombospondin type I module at the C-terminus, and the two short consensus repeat modules.
The mature protein consists of 913 amino acid residues preceded by a 21-residue signal sequence.
The mature protein consists of 913 amino acid residues preceded by a 21-residue signal sequence.
Application
Complement C6 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). It has been shown that complement C6 and the MAC are crucial for the development of arthritis in osteoarthritis and gouty arthritis. This could serve as a therapeutic target area for suppression of joint inflammation.
Analysis Note
Functionally active by a sensitive hemolytic assay.
Other Notes
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
T John et al.
Histology and histopathology, 22(7), 781-790 (2007-04-25)
The limited ability of articular cartilage to recover from injury, remains an unsolved clinical challenge in orthopaedic surgery. Persistent injury of the articular surface can lead to the development of posttraumatic osteoarthritis. The local inflammatory response contributes to the pathogenesis
Identification of a central role for complement in osteoarthritis.
Identification of a central role for complement in osteoarthritis.
Nature Materials, 17, 1674-1979 (2011)
Nicole Tramontini et al.
Arthritis and rheumatism, 50(8), 2633-2639 (2004-08-31)
Monosodium urate monohydrate (MSU) crystals promote gouty inflammation that is critically mediated by neutrophil recruitment and activation. Interleukin-8 (IL-8) and closely related chemokines are major neutrophil chemotaxins in experimental gout. But MSU crystals also activate the classical and alternative pathways
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持