C4282
辅酶 A 水合物
≥85% (UV, HPLC)
别名:
CoA
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关于此项目
经验公式（希尔记法）:
C21H36N7O16P3S · xH2O
化学文摘社编号:
分子量:
767.53 (anhydrous basis)
UNSPSC Code:
12352100
NACRES:
NA.21
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
77809
biological source
yeast
Quality Level
assay
≥85% (UV, HPLC)
form
powder
functional group
phospholipid
shipped in
dry ice
storage temp.
−70°C
SMILES string
O.CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n2cnc3c(N)ncnc23)[C@@H](O)C(=O)NCCC(=O)NCCS
InChI
1S/C21H36N7O16P3S.H2O/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);1H2/t11-,14-,15-,16+,20-;/m1./s1
InChI key
TVSAELAFGDOPKI-BLPRJPCASA-N
Application
辅酶A水合物已用于中华绒螯蟹体内重组乙酰乙酰辅酶A硫解酶（rACAT）的硫解酶测定。它可以用作拉曼光谱测定中的参考标准品。
Biochem/physiol Actions
辅酶A（CoA）是由半胱氨酸、泛酸和ATP合成的必需代谢辅助因子。
辅酶A（CoA）是由半胱氨酸、泛酸和ATP合成的必需代谢辅助因子。CoA在许多代谢途径中起重要作用，包括三羧酸循环，以及脂肪酸的合成和氧化。CoA的主要功能之一是酰基的携带和转移。酰化衍生物，例如乙酰-CoA，是许多代谢反应中的关键中间体。在饥饿期间以及癌症、糖尿病和酗酒等条件下，CoA水平可能会发生变化。
Disclaimer
游离酸不如钠盐或锂盐稳定；在−80 °C下储存时，6个月内会发生5％的分解。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Gregory R Wagner et al.
The Journal of biological chemistry, 288(40), 29036-29045 (2013-08-16)
Alterations in mitochondrial protein acetylation are implicated in the pathophysiology of diabetes, the metabolic syndrome, mitochondrial disorders, and cancer. However, a viable mechanism responsible for the widespread acetylation in mitochondria remains unknown. Here, we demonstrate that the physiologic pH and
Rajesh K Harijan et al.
The Biochemical journal, 455(1), 119-130 (2013-08-06)
Thiolases are essential CoA-dependent enzymes in lipid metabolism. In the present study we report the crystal structures of trypanosomal and leishmanial SCP2 (sterol carrier protein, type-2)-thiolases. Trypanosomatidae cause various widespread devastating (sub)-tropical diseases, for which adequate treatment is lacking. The
Ulrike Demmer et al.
The Journal of biological chemistry, 288(9), 6363-6370 (2013-01-18)
Autotrophic members of the Sulfolobales (crenarchaeota) use the 3-hydroxypropionate/4-hydroxybutyrate cycle to assimilate CO2 into cell material. The product of the initial acetyl-CoA carboxylation with CO2, malonyl-CoA, is further reduced to malonic semialdehyde by an NADPH-dependent malonyl-CoA reductase (MCR); the enzyme
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C4282-100MG | 04061833491935 |
| C4282-25MG | 04061833491959 |
| C4282-10MG | 04061833491942 |