C4282
辅酶 A 水合物
≥85% (UV, HPLC)
别名:
CoA
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关于此项目
经验公式（希尔记法）:
C21H36N7O16P3S · xH2O
化学文摘社编号:
分子量:
767.53 (anhydrous basis)
UNSPSC Code:
12352100
NACRES:
NA.21
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
77809
产品名称
辅酶 A 水合物, ≥85% (UV, HPLC)
InChI key
TVSAELAFGDOPKI-BLPRJPCASA-N
SMILES string
O.CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n2cnc3c(N)ncnc23)[C@@H](O)C(=O)NCCC(=O)NCCS
InChI
1S/C21H36N7O16P3S.H2O/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);1H2/t11-,14-,15-,16+,20-;/m1./s1
biological source
yeast
assay
≥85% (UV, HPLC)
form
powder
functional group
phospholipid
shipped in
dry ice
storage temp.
−70°C
Quality Level
Application
辅酶A水合物已用于中华绒螯蟹体内重组乙酰乙酰辅酶A硫解酶（rACAT）的硫解酶测定。它可以用作拉曼光谱测定中的参考标准品。
Biochem/physiol Actions
辅酶A（CoA）是由半胱氨酸、泛酸和ATP合成的必需代谢辅助因子。
辅酶A（CoA）是由半胱氨酸、泛酸和ATP合成的必需代谢辅助因子。CoA在许多代谢途径中起重要作用，包括三羧酸循环，以及脂肪酸的合成和氧化。CoA的主要功能之一是酰基的携带和转移。酰化衍生物，例如乙酰-CoA，是许多代谢反应中的关键中间体。在饥饿期间以及癌症、糖尿病和酗酒等条件下，CoA水平可能会发生变化。
Disclaimer
游离酸不如钠盐或锂盐稳定；在−80 °C下储存时，6个月内会发生5％的分解。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ulrike Demmer et al.
The Journal of biological chemistry, 288(9), 6363-6370 (2013-01-18)
Autotrophic members of the Sulfolobales (crenarchaeota) use the 3-hydroxypropionate/4-hydroxybutyrate cycle to assimilate CO2 into cell material. The product of the initial acetyl-CoA carboxylation with CO2, malonyl-CoA, is further reduced to malonic semialdehyde by an NADPH-dependent malonyl-CoA reductase (MCR); the enzyme
Gregory R Wagner et al.
The Journal of biological chemistry, 288(40), 29036-29045 (2013-08-16)
Alterations in mitochondrial protein acetylation are implicated in the pathophysiology of diabetes, the metabolic syndrome, mitochondrial disorders, and cancer. However, a viable mechanism responsible for the widespread acetylation in mitochondria remains unknown. Here, we demonstrate that the physiologic pH and
Haruyuki Atomi et al.
Biochemical Society transactions, 41(1), 427-431 (2013-01-30)
CoA is a ubiquitous molecule in all three domains of life and is involved in various metabolic pathways. The enzymes and reactions involved in CoA biosynthesis in eukaryotes and bacteria have been identified. By contrast, the proteins/genes involved in CoA
Rajesh K Harijan et al.
The Biochemical journal, 455(1), 119-130 (2013-08-06)
Thiolases are essential CoA-dependent enzymes in lipid metabolism. In the present study we report the crystal structures of trypanosomal and leishmanial SCP2 (sterol carrier protein, type-2)-thiolases. Trypanosomatidae cause various widespread devastating (sub)-tropical diseases, for which adequate treatment is lacking. The
Francis McCoy et al.
Molecular cell, 52(3), 325-339 (2013-10-08)
Active metabolism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caspase-2, but the link between metabolic activity and CaMKII is poorly understood. Here we identify coenzyme A (CoA) as the key metabolic signal that inhibits Xenopus
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