生物来源
mouse
质量水平
重组
expressed in NS.1 cells
方案
≥99% (SDS-PAGE)
表单
buffered aqueous solution
分子量
97 kDa
包装
pkg of 1 mg
储存条件
avoid repeated freeze/thaw cycles
杂质
≤1 EU/mg protein Endotoxin level (LAL test)
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Cd152(12477), Ctla4(12477)
一般描述
The complement (C1q) and FcγR I binding sites of the Fcγ2a fragment allow the Fc portion of the fusion protein to effectively facilitate direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
生化/生理作用
CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.
外形
Solution, 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added.
制备说明
Purified from serum-free tissue culture supernatant
其他说明
The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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