C5366
Chlorisondamine diiodide
≥98% (HPLC), nicotinic acetylcholine receptor antagonist, solid
别名:
4,5,6,7-Tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-2H-isoindolium diiodide
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关于此项目
经验公式（希尔记法）:
C14H20Cl4I2N2
化学文摘社编号:
分子量:
611.94
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
protect from light
产品名称
Chlorisondamine diiodide, ≥98% (HPLC), white, solid
Quality Segment
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
white
solubility
H2O: ≥2 mg/mL, DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
[I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1
InChI
1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
InChI key
FPNVAOZHQUJJJQ-UHFFFAOYSA-L
Application
Chlorisondamine diiodide has been used:
- as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
- as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
- as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress
Biochem/physiol Actions
Irreversible, long-lasting nicotinic acetylcholine receptor antagonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves