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C5749

CGP 52608

Name: CGP 52608
Brand: SIGMA

≥98%, RORA activator, solid

别名:

1-[3-Allyl-4-oxo-thiazolidine-2-ylidene]-4-methyl-thiosemicarbazone, N-Methyl-2-[4-oxo-3-(2-propen-1-yl)-2-thiazolidinylidene]-hydrazinecarbothioamide

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关于此项目

经验公式（希尔记法）:

C₈H₁₂N₄OS₂

化学文摘社编号:

87958-67-6

分子量:

244.34

UNSPSC Code:

12352200

PubChem Substance ID:

329775098

NACRES:

NA.77

MDL number:

MFCD00942304

Assay:

≥98%

Form:

solid

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属性

产品名称

CGP 52608, ≥98%, solid

Quality Segment

100

assay

≥98%

form

solid

solubility

DMSO: >30 mg/mL, H₂O: insoluble

storage temp.

−20°C

SMILES string

CNC(=S)N\N=C1/SCC(=O)N1CC=C

InChI

1S/C8H12N4OS2/c1-3-4-12-6(13)5-15-8(12)11-10-7(14)9-2/h3H,1,4-5H2,2H3,(H2,9,10,14)/b11-8-

InChI key

DDYJDIHOSRTMSE-FLIBITNWSA-N

说明

Application

CGP 52608 has been used as a RAR related orphan receptor α (RORα) synthetic agonist in THP-1 macrophages, in human monocyte cells THP1 and somatic testicular cells.

Biochem/physiol Actions

CGP 52608 is a thiazolidine derivative and an antiarthritic compound. It possesses immunostimulatory functionality and elicits antiproliferative effect in colon tumors. It is cytotoxic towards neural cell lines. CGP 52608 induces apoptosis in tumor and also favors G0-G1 cell cycle phase accumulation in neural cell lines.

CGP 52608 is a specific activator of retinoic acid receptor-related orphan receptor α (RORA).

Features and Benefits

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

怎么回事？

WGK 3

闪点 (F)

Not applicable

闪点 (°C)