C5813
Complement factor H 来源于人类血浆
1 mg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)
应用
Complement factor H (CFH) is a plasma regulator of the complement protein C3b in the alternative pathway of the complement system. Research has shown that binding of CFH is important for pathogenesis of group A streptococcus (GAS), and inhibition of this binding may be an effective management of GAS infections.
生化/生理作用
C3b-binding protein which regulates the formation and function of complement C3 and C5 convertases.
Complement factor H plays an essential role in the homeostasis of the complement system and in preventing collateral damage to bystander cells and tissues by complement activation.
其他说明
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
免责声明
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
高风险级别生物产品--人源产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Acquisition of Complement Factor H Is Important for Pathogenesis of Streptococcus pyogenes Infections: Evidence from Bacterial In Vitro Survival and Human Genetic Association.
Haapasalo K., et al.
Journal of Immunology (2011)
Johanna M Seddon et al.
JAMA ophthalmology, 131(4), 448-455 (2013-02-16)
Risk score models predicting the progression of age-related macular degeneration (AMD) to its advanced forms may be useful for targeting high-risk individuals for lifestyle changes that reduce risk for AMD progression, helping with differential diagnosis of AMD and its subtypes
Katy Vaillancourt et al.
Journal of medical microbiology, 62(Pt 7), 1073-1080 (2013-04-27)
Streptococcus suis is a major swine pathogen and an emerging zoonotic agent. The ability of pathogenic bacteria to bind the complement regulator factor H on their cell surface may allow them to avoid complement attack and phagocytosis. The aim of
Pangburn, M.K. and muller-Eberhard, H.J.
Springer Semin. Immunopath., 7, 63-63 (1984)
Ruodan Nan et al.
The Journal of biological chemistry, 288(26), 19197-19210 (2013-05-11)
The sub-retinal pigment epithelial deposits that are a hallmark of age-related macular degeneration contain both C3b and millimolar levels of zinc. C3 is the central protein of complement, whereas C3u is formed by the spontaneous hydrolysis of the thioester bridge
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