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Merck
CN

C6143

氯己定 二乙酸盐 水合物

bis(biguanide) antimicrobial

别名:

1,6-双（N5-[对氯苯基]-N1-双胍）己烷；1,1′-六亚甲基双（5-[对氯苯基] 双胍）

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关于此项目

经验公式（希尔记法）:
C22H30Cl2N10 · 2C2H4O2 · xH2O
化学文摘社编号:
206986-79-0
分子量:
625.55 (anhydrous basis)
NACRES:
NA.85
PubChem Substance ID:
24892838
UNSPSC Code:
51102829
EC Number:
200-302-4
MDL number:
MFCD00012532

主要文件

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产品名称

氯己定 二乙酸盐 水合物, bis(biguanide) antimicrobial

InChI key

WDRFFJWBUDTUCA-UHFFFAOYSA-N

InChI

1S/C22H30Cl2N10.2C2H4O2/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*1-2(3)4/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H3,(H,3,4)

SMILES string

ClC1=CC=C(NC(NC(NCCCCCCNC(NC(NC2=CC=C(Cl)C=C2)=N)=N)=N)=N)C=C1.OC(C)=O.OC(C)=O

form

powder

CMC

0.01% (25°C)(w/v)

solubility

ethanol: 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell membrane | interferes

storage temp.

room temp

Quality Level

200

相关类别

Application

可用于研究双（双胍）分子破坏膜的作用机制。

Biochem/physiol Actions

氯己定是一种阳离子广谱抗菌药物，属于双（双胍类）家族。其作用机制涉及外层细菌膜的不稳定。对革兰阳性菌和革兰阴性菌均有效。氯己定主要作为局部抗菌剂/消毒剂用于伤口愈合、导管插入部位、各种牙科应用和外科擦洗剂。

Disclaimer

本品不可用作全球生物杀灭剂法规监管的生物杀灭剂，包括但不限于：美国联邦杀虫剂、杀菌剂和灭鼠剂法(US EPA′s Federal Insecticide Fungicide and Rodenticide Act)、欧盟生物杀灭剂法规(European Biocidal Products Regulation)、加拿大虫害管理监管机构(Canada’s Pest Management Regulatory Agency)、土耳其生物杀灭剂法规(Turkey’s Biocidal Products Regulation)、韩国生物杀灭剂法(Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR))等。

Other Notes

将容器密闭保存在干燥和通风良好的地方。在干燥处保存。

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 2

target_organs

Liver,Teeth

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000524340
0000523297
0000523297
0000524340
WXBF5142V

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E Zaura-Arite et al.
Journal of dental research, 80(5), 1436-1440 (2001-07-05)
Culturing of dispersed plaque samples and vitality staining of plaque smears are the most commonly used methods for evaluating the effects of antimicrobials on dental plaque. The visualization of the antimicrobial action on oral biofilm present on the substrate surface
Angela R Schug et al.
Veterinary microbiology, 248, 108791-108791 (2020-08-23)
Biocide susceptibility testing (BST) of bacteria lacks standardised methods. Based on a recently established broth macrodilution BST method, a broth microdilution method for BST was developed. To establish the respective protocol, four reference strains Staphylococcus aureus ATCC® 6538, Enterococcus hirae
T J Karpanen et al.
The Journal of antimicrobial chemotherapy, 62(5), 1031-1036 (2008-08-16)
Effective skin antisepsis and disinfection of medical devices are key factors in preventing many healthcare-acquired infections associated with skin microorganisms, particularly Staphylococcus epidermidis. The aim of this study was to investigate the antimicrobial efficacy of chlorhexidine digluconate (CHG), a widely
C Harrison et al.
International journal of STD & AIDS, 9(2), 92-97 (1998-03-20)
The effect of chlorhexidine and nonoxynol-9, either singly or in combination, on the replication and infectivity of HIV and the survival of both lymphocytes (MT2 cells) and human spermatozoa, was studied in vitro. Exposure of MT2 cells to 200 microg/ml
Synthesis, characterization and antibacterial properties of dihydroxy quaternary ammonium salts with long chain alkyl bromides.
Liu WS, Wang CH, Sun JF, et al.
Chemical Biology & Drug Design, 85(1), 91-97 (2014)
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