C6594
抗-c-Myc
clone 9E10, purified immunoglobulin, buffered aqueous solution
别名:
Anti-c-Myc
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
CY3 conjugate
Clone:
9E10, monoclonal
Application:
direct immunofluorescence
Species reactivity:
human
Citations:
24
Technique(s):
direct immunofluorescence: 1:50 using formalin-fixed, paraffin-embedded human colon carcinoma tissue
Uniprot accession no.:
产品名称
抗-c-Myc, clone 9E10, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
CY3 conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
9E10, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
direct immunofluorescence: 1:50 using formalin-fixed, paraffin-embedded human colon carcinoma tissue
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MYC(4609)
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Immunogen
人p62c-Myc蛋白的合成肽。
Application
Monoclonal Anti-c-MycCy3™ antibody produced in mouse has been used in:
- western blotting
- immunocytochemistry
- Immunofluorescence
Biochem/physiol Actions
The encoded protein is involved in cell proliferation, growth and apoptosis. The c-myc gene has been implicated in the development of a number of neoplasms in a variety of avian and mammalian species. The human c-myc protooncogene is the cellular homolog of the avian v-myc gene found in several leukemogenic retroviruses. Increased expression of the cellular oncogene c-myc has been described in a variety of human tumors, occurring by several different mechanisms, including gene amplification and chromosomal translocation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-c-myc (mouse IgG1 isotype) is derived from the 9E10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/c mouse. The c-Myc gene encodes a polypeptide with a predicted molecular weight of 49 kDa.
Physical form
Solution in 0.01 M sodium phosphate buffered saline containing 1% bovine serum albumin and 15 mM sodium azide.
Legal Information
Cy3 is a trademark of Cytiva
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
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One of the hallmarks of cancer is an altered energy metabolism, and here, mitochondria play a central role. Previous studies have indicated that some mitochondrial ribosomal proteins change their expression patterns upon transformation. In this study, we have used the
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Caruso JA, et al.
Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, 473(1), 85-99 (2001)
Joe DeBartolo et al.
PLoS computational biology, 10(6), e1003693-e1003693 (2014-06-27)
Programmed cell death is regulated by interactions between pro-apoptotic and prosurvival members of the Bcl-2 family. Pro-apoptotic family members contain a weakly conserved BH3 motif that can adopt an alpha-helical structure and bind to a groove on prosurvival partners Bcl-xL
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