生物来源
mouse
质量水平
偶联物
CY3 conjugate
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
9E10, monoclonal
表单
buffered aqueous solution
种属反应性
human
技术
direct immunofluorescence: 1:50 using formalin-fixed, paraffin-embedded human colon carcinoma tissue
UniProt登记号
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... MYC(4609)
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一般描述
Monoclonal Anti-c-myc (mouse IgG1 isotype) is derived from the 9E10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/c mouse. The c-Myc gene encodes a polypeptide with a predicted molecular weight of 49 kDa.
免疫原
人p62c-Myc蛋白的合成肽。
应用
Monoclonal Anti-c-MycCy3™ antibody produced in mouse has been used in:
- western blotting
- immunocytochemistry
- Immunofluorescence
生化/生理作用
The encoded protein is involved in cell proliferation, growth and apoptosis. The c-myc gene has been implicated in the development of a number of neoplasms in a variety of avian and mammalian species. The human c-myc protooncogene is the cellular homolog of the avian v-myc gene found in several leukemogenic retroviruses. Increased expression of the cellular oncogene c-myc has been described in a variety of human tumors, occurring by several different mechanisms, including gene amplification and chromosomal translocation.
外形
Solution in 0.01 M sodium phosphate buffered saline containing 1% bovine serum albumin and 15 mM sodium azide.
法律信息
Cy3 is a trademark of Cytiva
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Correlation of mutant menin stability with clinical expression of multiple endocrine neoplasia type 1 and its incomplete forms
Shimazu S, et al.
Cancer Science, 102(11), 2097-2102 (2011)
Joe DeBartolo et al.
PLoS computational biology, 10(6), e1003693-e1003693 (2014-06-27)
Programmed cell death is regulated by interactions between pro-apoptotic and prosurvival members of the Bcl-2 family. Pro-apoptotic family members contain a weakly conserved BH3 motif that can adopt an alpha-helical structure and bind to a groove on prosurvival partners Bcl-xL
Marie Pierron et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(24), 6525-6537 (2016-06-17)
Diffuse extrasynaptic neurotransmitter receptors constitute an abundant pool of receptors that can be recruited to modulate synaptic strength. Whether the diffuse distribution of receptors in extrasynaptic membranes is a default state or is actively controlled remains essentially unknown. Here we
Sanjib Dutta et al.
Journal of molecular biology, 398(5), 747-762 (2010-04-07)
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Prosurvival members of the family interact with proapoptotic BH3 (Bcl-2-homology-3)-only members, inhibiting execution of cell death through the mitochondrial pathway. Structurally, this interaction is mediated by binding of the alpha-helical
Treena Chatterjee et al.
The Journal of biological chemistry, 296, 100261-100261 (2021-04-11)
GPR56 is a member of the adhesion G-protein-coupled receptor family shown to play important roles in cell adhesion, brain development, immune function, and tumorigenesis. GPR56 is highly upregulated in colorectal cancer and correlates with poor prognosis. Several studies have shown
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