C6607
Caspase 10 human
>90% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, 8,000 units/mg protein (Bradford)
别名:
Flice2, Mch4
并加购，请在购物车里查看协议价、货期和发货地。
选择规格
变更视图
关于此项目
Specific activity:
8,000 units/mg protein (Bradford)
Assay:
>90% (SDS-PAGE)
Recombinant:
expressed in E. coli
recombinant
expressed in E. coli
Quality Segment
assay
>90% (SDS-PAGE)
form
lyophilized powder
specific activity
8,000 units/mg protein (Bradford)
mol wt
~30 kDa
solubility
PBS: soluble
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CASP10(843)
Biochem/physiol Actions
Caspase 10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase 10 cleaves and activates caspases 3, 4, 6, 7, 8 and 9 which causes the proteolytic cleavage of many key proteins such as PARP. Based on gene expression studies, caspase 10 may be crucial in embryonic development. In view of its structural homology to caspase 8, the initiator caspase in death receptor-mediated apoptosis, caspase 10 may function in a similar and redundant manner.
Physical form
Lyophilized powder containing 0.052% ammonium sulfate, 0.158% Tris−HCl, and 0.76% sodium chloride.
Other Notes
One unit will hydrolyze 1 nmol of the caspase substrate IETD-pNA to IETD and p-nitroaniline per hour at pH 7.2 at 37 °C.
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable