C6616
Chrysomycin A
≥98% (HPLC), solid
方案
≥98% (HPLC)
表单
solid
溶解性
DMF: soluble
DMSO: soluble
ethanol: moderately soluble
methanol: moderately soluble
抗生素抗菌谱
neoplastics
作用机制
enzyme | inhibits
储存温度
2-8°C
SMILES字符串
COc1cc(C=C)cc2C(=O)Oc3c(cc(OC)c4c(O)ccc([C@@H]5O[C@H](C)[C@H](O)[C@@](C)(O)[C@H]5O)c34)-c12
InChI
1S/C28H28O9/c1-6-13-9-16-20(18(10-13)34-4)15-11-19(35-5)22-17(29)8-7-14(21(22)23(15)37-27(16)32)24-26(31)28(3,33)25(30)12(2)36-24/h6-12,24-26,29-31,33H,1H2,2-5H3/t12-,24+,25+,26+,28-/m1/s1
InChI key
OMDANBMKOUVKAG-WZNMFJNZSA-N
生化/生理作用
Antibiotic from Streptomyces sp. Inhibits the catalytic activity of human topoisomerase II.
Antibiotic from Streptomyces sp. Inhibits the catalytic activity of human topoisomerase II. Exhibits antitumor activity against human cell lines K562, HT29, MCF7, PC6, and MKN28.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
R K Elespuru et al.
Science (New York, N.Y.), 223(4631), 69-71 (1984-01-06)
Gilvocarcins that are antitumor agents are activated by low doses of visible light to induce bacteriophage lambda in Escherichia coli. This result is dependent on interaction with DNA. Gilvocarcin M, an analog without antitumor activity, failed to induce the prophage
Studies on the mechanism of actin of gilvocarcin V and chrysomycin A.
T T Wei et al.
The Journal of antibiotics, 35(4), 545-548 (1982-04-01)
Madan K Kharel et al.
Natural product reports, 29(2), 264-325 (2011-12-22)
Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativity and biosynthetic inquisitiveness. The synthetic studies used five different strategies, involving Diels-Alder
Antitumor activity of chrysomycins M and V.
J A Matson et al.
The Journal of antibiotics, 42(9), 1446-1448 (1989-09-01)
U Weiss et al.
The Journal of antibiotics, 35(9), 1194-1201 (1982-09-01)
The yellow antibiotic chrysomycin, isolated in crystalline form in 1955, is found to consist of two closely related components, a major one, chrysomycin A, and a minor one, chrysomycin B. They differ only through the replacement of a vinyl group
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