Anti-Chloride Channel-K (CLC-K) antibody produced in rabbit

The gene Chloride channel Kb (CLCNKB) is mapped to human chromosome 1p36. It is a kidney specific protein and is present in basolateral membranes of renal tubules.

synthetic peptide corresponding to amino acids 674-687 of rat longer form CLC-K2L (with additional C-terminal cysteine). The epitope sequence corresponds to the CLC-K2 isotype. It differs by only one residue from rat CLC-K1, or from corresponding human or mouse CLC-Ka or CLC-Kb.

Anti-Chloride Channel-K (CLC-K) antibody produced in rabbit is suitable for the following applications:

• Immunohistochemistry
• Immunoprecipitation
• Western blotting (chemiluminescent) at a dilution of 1:200

Mutations in chloride channel Kb (CLCNKB) gene cause Bartter syndrome (is a salt-losing renal tubulopathy) and is associated with hypertension (EH). Two classes of CLCNKB mutants are distinguished namely, nonconducting mutants associated with low total protein expression and partially conducting mutants with unaltered channel properties and ClC-Kb protein abundance.

Lyophilized at ~0.6 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose, and 0.025% sodium azide.

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