C7743
CHPG
≥98% (HPLC), white, solid
别名:
α-amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C8H8ClNO3
化学文摘社编号:
分子量:
201.61
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: ≥10 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
NC(C(O)=O)c1cc(O)ccc1Cl
InChI
1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
InChI key
UNIDAFCQFPGYJJ-UHFFFAOYSA-N
生化/生理作用
CHPG is a selective, potent mGluR5 agonist.
CHPG is a selective, potent mGluR5 agonist. CHO cells expressing mGluR5 (but not those expressing mGluR1) are activated by CHPG. In vivo, CHPG stimulates thalamic neurons and is antagonized by MPEP (selective mGluR5 antagonist); CHPG potentiates NMDA and AMPA responses in spinal cord and produces oscillations in intracellular calcium in dorsal root ganglion cells.
特点和优势
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Chunjie Li et al.
Molecular neurobiology, 54(7), 5286-5299 (2016-09-01)
Glutamate is one of the major excitatory neurotransmitters of the CNS and is essential for numerous key neuronal functions. However, excess glutamate causes massive neuronal death and brain damage owing to excitotoxicity via the glutamate receptors. Metabotropic glutamate receptor 5
Yan-Gang Sun et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(30), 7886-7896 (2016-07-29)
Acetylcholine (ACh) signaling is involved in a wide range of processes, including arousal, attention, and learning. An increasing number of studies indicate that cholinergic control of these functions is highly deterministic, mediated by synaptic afferents that generate reliable and precise
Xavier Morató et al.
Human molecular genetics, 27(20), 3528-3541 (2018-07-17)
The hippocampus is a key brain region for memory formation. Metabotropic glutamate type 5 receptors (mGlu5R) are strongly expressed in CA1 pyramidal neurons and fine-tune synaptic plasticity. Accordingly, mGlu5R pharmacological manipulation may represent an attractive therapeutic strategy to manage hippocampal-related
Kuniya Honda et al.
Pain, 158(9), 1754-1764 (2017-06-18)
Peripheral tissue inflammation or injury causes glutamate release from nociceptive axons, keratinocytes, and Schwann cells, resulting in thermal hypersensitivity. However, the detailed molecular mechanisms underlying glutamate-induced thermal hypersensitivity are unknown. The aim of this study was to clarify the involvement
Michael A Benneyworth et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(24), 4785-4796 (2019-04-06)
Understanding the neurobiological processes that incite drug craving and drive relapse has the potential to help target efforts to treat addiction. The NAc serves as a critical substrate for reward and motivated behavior, in part due to alterations in excitatory
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持