Anti-CIDE-A, C-Terminal antibody produced in rabbit

synthetic peptide corresponding to amino acids 200-214 of the C-terminal of mouse CIDE-A.

Anti-CIDE-A, C-Terminal antibody was used in western blot at 0.5 μg/ml, immunohistochemistry starting at 2.5 μg/ml and for immunofluorescence start at 20 μg/mL.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Apoptosis or Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family proteases. These signals are generated by DNase in chromosomal DNA degradation. CIDE-A and CIDE-B induce DNA fragmentation and activate apoptosis in mammalian cells. The C-terminal region of CIDE-A is necessary and sufficient for killing. DFF45/ICAD is an inhibitor of caspase activated Dnase, DFF40/CAD and has also been shown to inhibit the apoptotic activities of CIDE-A and CIDE-B. The region of CIDE-A with homology to DFF45 located in the N-terminus was required for DFF45 to inhibit CIDE-A induced apoptosis. CIDE-A is expressed in a number of tissues including kidney and heart.

Solution in phosphate buffered saline containing 0.02% sodium azide.

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