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Merck
CN

C8221

咖啡酸苯乙酯

synthetic, ≥97% (HPLC), Nuclear transcription factor NF-κB inhibitor, powder

别名:

CAPE

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关于此项目

经验公式（希尔记法）:
C17H16O4
化学文摘社编号:
104594-70-9
分子量:
284.31
MDL编号:
MFCD00866470
UNSPSC代码:
12352108
PubChem化学物质编号:
24278341
NACRES:
NA.77

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产品名称

咖啡酸苯乙酯, ≥97% (HPLC), powder

生物来源

synthetic

质量水平

200

方案

≥97% (HPLC)

表单

powder

储存条件

protect from light

颜色

off-white

溶解性

ethyl acetate: 50 mg/mL
DMSO: soluble
ethanol: soluble

储存温度

−20°C

SMILES字符串

Oc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O

InChI

1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+

InChI key

SWUARLUWKZWEBQ-VQHVLOKHSA-N

基因信息

human ... NFKB2(4791)

相关类别

应用

咖啡酸苯乙酯(CAPE)已用于测定CAPE对甲亢的作用，作为培养基组分检测乳腺癌细胞系MDA-MB-231的细胞毒性，研究其对大鼠胺碘酮诱导肺纤维化的影响。

生化/生理作用

CAPE具有多种特性，如抗癌、免疫调节活性、抗氧化、抗病毒、抗炎、降血糖作用、心脏保护功能以及胃分泌抑制作用。它还对一种乳腺癌肿瘤生长因子——成纤维细胞生长因子2(FGF-2)具有抑制作用。
咖啡酸苯乙酯是核转录因子 NF-κ B的特异性抑制剂。

特点和优势

该化合物是基因调控研究的特色产品。 点击此处 ，发现更多特色基因调控产品。在 sigma.com/discover-bsm 了解更多关于其他研究领域的生物活性小分子。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM2256
BCCK6390
BCCC6847
BCBV6787
BCBR2913V

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Attenuation of oxidative stress in plasma and tissues of rats with experimentally induced hyperthyroidism by caffeic acid phenylethyl ester
Mohamadin AM, et al.
Basic and Clinical Pharmacology and Toxicology, 100(2), 84-90 (2007)
K Natarajan et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(17), 9090-9095 (1996-08-20)
Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory properties. The molecular basis for these diverse properties is not known. Since the role of the nuclear factor
M T Hansen et al.
Oncogene, 34(4), 424-435 (2014-01-29)
S100A4 is implicated in metastasis and chronic inflammation, but its function remains uncertain. Here we establish an S100A4-dependent link between inflammation and metastatic tumor progression. We found that the acute-phase response proteins serum amyloid A (SAA) 1 and SAA3 are
O K Mirzoeva et al.
Prostaglandins, leukotrienes, and essential fatty acids, 55(6), 441-449 (1996-12-01)
To investigate the possible mechanism of the therapeutic action of propolis, we studied: (a) the effect of propolis, its components, caffeic acid phenethyl ester (CAPE), caffeic acid (CA), quercetin and naringenin, as well as the synthetic compounds indomethacin (IM) and
Protective effect of caffeic acid phenethyl ester (CAPE) on amiodarone-induced pulmonary fibrosisin rat
Zaeemzadeh N, et al.
Iranian Journal of Pharmaceutical Research : IJPR, 10(2), 321-321 (2011)
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