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C8221

Sigma-Aldrich

咖啡酸苯乙酯

≥97% (HPLC), powder

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别名:
CAPE
经验公式（希尔记法）:
C17H16O4
CAS号:
104594-70-9
分子量:
284.31
MDL编号:
MFCD00866470
PubChem化学物质编号:
24278341
NACRES:
NA.77

生物来源

synthetic

质量水平

200

检测方案

≥97% (HPLC)

形式

powder

储存条件

protect from light

颜色

off-white

溶解性

ethyl acetate: 50 mg/mL
DMSO: soluble
ethanol: soluble

储存温度

−20°C

SMILES字符串

Oc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O

InChI

1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+

InChI key

SWUARLUWKZWEBQ-VQHVLOKHSA-N

基因信息

human ... NFKB2(4791)

应用

咖啡酸苯乙酯(CAPE)已用于测定CAPE对甲亢的作用，作为培养基组分检测乳腺癌细胞系MDA-MB-231的细胞毒性，研究其对大鼠胺碘酮诱导肺纤维化的影响。

生化/生理作用

CAPE具有多种特性，如抗癌、免疫调节活性、抗氧化、抗病毒、抗炎、降血糖作用、心脏保护功能以及胃分泌抑制作用。它还对一种乳腺癌肿瘤生长因子——成纤维细胞生长因子2(FGF-2)具有抑制作用。
咖啡酸苯乙酯是核转录因子 NF-κ B的特异性抑制剂。

特点和优势

该化合物是基因调控研究的特色产品。 点击此处 ，发现更多特色基因调控产品。在 sigma.com/discover-bsm 了解更多关于其他研究领域的生物活性小分子。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Z Z Su et al.
Anticancer research, 15(5B), 1841-1848 (1995-09-01)
The active component of the folk medicine propolis, caffeic acid phenethyl ester (CAPE), displays selective toxicity toward cloned rat embryo fibroblast (CREF) cells transformed by a spectrum of diverse acting oncogenes. Identification of the mode of action of CAPE should
D Grunberger et al.
Experientia, 44(3), 230-232 (1988-03-15)
The honeybee hive product, propolis, is a folk medicine employed for treating various ailments. Many important pharmaceutical properties have been ascribed to propolis, including anti-inflammatory, antiviral, immunostimulatory and carcinostatic activities. Propolis extracts have provided an active component identified as caffeic
G F Sud'ina et al.
FEBS letters, 329(1-2), 21-24 (1993-08-23)
Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5-lipoxygenase in the micromolar concentration range. The inhibition is of an uncompetitive type, i.e. the inhibitor binds to the enzyme-substrate complex but not to the free enzyme. Caffeic acid
M R Fesen et al.
Biochemical pharmacology, 48(3), 595-608 (1994-08-03)
The inhibition of HIV-1 integrase by flavones and related compounds was investigated biochemically and by means of structure-activity relationships. Purified enzyme and synthetic oligonucleotides were used to assay for three reactions catalysed by integrase: (1) processing of 3' termini by
Protective effect of caffeic acid phenethyl ester (CAPE) on amiodarone-induced pulmonary fibrosisin rat
Zaeemzadeh N, et al.
Iranian Journal of Pharmaceutical Research : IJPR, 10(2), 321-321 (2011)
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