Monoclonal Anti-COX II antibody produced in mouse

COX-II is an isoform of COX enzyme with 604 amino acid residues that catalyzes the conversion of arachinodate to prostaglandin H2.

recombinant full length human COX II, 604 amino acids.

Monoclonal Anti-COX II antibody produced in mouse is suitable for immunoblotting at a working concentration of 1 to 5 μg/mL, indirect ELISA, microarray and flow cytometry at 1 μg/test.

COX-II is a target of NSAID (non-steroidal anti-inflammatory drugs) such as aspirin. It is induced in migratory cells responding to pro-inflammatory stimuli and is an important mediator of inflammation. The prostaglandins produced by COX-II are responsible for the pain and swelling from inflammation. As this enzyme is involved in the production of inflammatory agents, it is the target of intense research and drug discovery activities. COX-II is expressed in new angiogenic endothelial cells, synoviocytes from rheumatoid arthritis patients. It is also markedly expressed in 85% to 90% of human colorectal adenocarcinomas.

Solution in phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.

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