方案
≥98%
表单
liquid
颜色
, clear colorless to yellow-green
密度
0.85 g/mL at 25 °C (lit.)
储存温度
2-8°C
SMILES字符串
CCCC1CCCCN1
InChI
1S/C8H17N/c1-2-5-8-6-3-4-7-9-8/h8-9H,2-7H2,1H3
InChI key
NDNUANOUGZGEPO-UHFFFAOYSA-N
应用
Coniine, a neurotoxic alkaloid from hemlock, is used in comparative analysis versus other alkaloids that act at the level of the nicotinic acid/nicotinic acetylcholine (nAChR) receptors.
其他说明
Toxic principle of poison hemlock (racemic modification).
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2 - Flam. Liq. 3
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
119.3 °F - closed cup
闪点(°C)
48.5 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
涉药品监管产品
此项目有
K E Panter et al.
Toxicon : official journal of the International Society on Toxinology, 28(12), 1377-1385 (1990-01-01)
Three piperidine alkaloid containing plants, Conium maculatum (poison-hemlock), Nicotiana glauca (tree tobacco) and Lupinus formosus (lunara lupine), induced multiple congenital contractures (MCC) and palatoschisis in goat kids when their dams were gavaged with the plant during gestation days 30-60. The
Okan Arihan et al.
Journal of ethnopharmacology, 125(2), 274-278 (2009-07-08)
Hemlock was used as an analgesic in certain ethnopharmacological traditions and there has been no record about the antinociceptive effect of coniine which is the major alkaloid compound of Hemlock. The present study was undertaken to evaluate the possible antinociceptive
Stephen T Lee et al.
Chemical research in toxicology, 21(10), 2061-2064 (2008-09-04)
Coniine, one of the major toxic alkaloids present in poison hemlock ( Conium maculatum), occurs in two optically active forms. A comparison of the relative potencies of (+)- and (-)-coniine enantiomers has not been previously reported. In this study, we
C S Forsyth et al.
Teratology, 49(4), 306-310 (1994-04-01)
Coniine, an alkaloid from Conium maculatum (poison hemlock), has been shown to be teratogenic in livestock. The major teratogenic outcome is arthrogryposis, presumably due to nicotinic receptor blockade. However, coniine has failed to produce arthrogryposis in rats or mice and
Ingestion of poison hemlock (Conium maculatum).
B S Frank et al.
The Western journal of medicine, 163(6), 573-574 (1995-12-01)
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