C9392
(±)-Coniine
≥98%, liquid
别名:
2-Propylpiperidine
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关于此项目
经验公式（希尔记法）:
C8H17N
化学文摘社编号:
分子量:
127.23
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
221-801-3
MDL number:
InChI key
NDNUANOUGZGEPO-UHFFFAOYSA-N
InChI
1S/C8H17N/c1-2-5-8-6-3-4-7-9-8/h8-9H,2-7H2,1H3
SMILES string
CCCC1CCCCN1
assay
≥98%
form
liquid
color
, clear colorless to yellow-green
density
0.85 g/mL at 25 °C (lit.)
storage temp.
2-8°C
Application
Coniine, a neurotoxic alkaloid from hemlock, is used in comparative analysis versus other alkaloids that act at the level of the nicotinic acid/nicotinic acetylcholine (nAChR) receptors.
Other Notes
Toxic principle of poison hemlock (racemic modification).
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2 - Flam. Liq. 3
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
119.3 °F - closed cup
flash_point_c
48.5 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
涉药品监管产品
此项目有
Leo J Schep et al.
Clinical toxicology (Philadelphia, Pa.), 47(8), 771-781 (2009-09-26)
A wide range of plants contain nicotinic and nicotinic-like alkaloids. Of this diverse group, those that have been reported to cause human poisoning appear to have similar mechanisms of toxicity and presenting patients therefore have comparable toxidromes. This review describes
T Blitzke et al.
Phytochemistry, 55(8), 979-982 (2001-01-05)
Phytochemical investigations of Aloe sabaea afforded a new chlorinated amide, N-4'-chlorobutylbutyramide, and the toxic piperidine alkaloids coniine, gamma-coniceine and the quarternary N,N-dimethylconiine. This is the first report of the occurrence of a chlorinated compound in the Aloeaceae family.
Versatile one-pot reductive alkylation of lactams/amides via amide activation: application to the concise syntheses of bioactive alkaloids (±)-bgugaine, (±)-coniine, (+)-preussin, and (-)-cassine.
Kai-Jiong Xiao et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 16(43), 12792-12796 (2010-10-13)
Patrick L West et al.
Pediatric emergency care, 25(11), 761-763 (2009-11-17)
The ingestion of poison hemlock, or Conium maculatum, is described in a 2-year-old boy. He had the onset of abdominal pain and weakness after being fed C. maculatum picked by his sister from the roadside 2 hours earlier. He had
Ingestion of poison hemlock (Conium maculatum).
B S Frank et al.
The Western journal of medicine, 163(6), 573-574 (1995-12-01)
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