D0567
DIF-3
≥99% (HPLC), solid
别名:
1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone, Differentiation-inducing factor 3
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关于此项目
经验公式（希尔记法）:
C13H17ClO4
CAS Number:
分子量:
272.72
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥99% (HPLC)
表单
solid
溶解性
DMSO: soluble 46 mg/mL
SMILES字符串
CCCCCC(=O)c1c(O)cc(OC)c(Cl)c1O
InChI
1S/C13H17ClO4/c1-3-4-5-6-8(15)11-9(16)7-10(18-2)12(14)13(11)17/h7,16-17H,3-6H2,1-2H3
InChI key
JWBMZIJMSBFBIY-UHFFFAOYSA-N
一般描述
Differentiation-inducing factor-3 (DIF-3) is a monochlorinated metabolite of differentiation-inducing factor-1 (DIF-1), that belongs to the differentiation-inducing factor (DIF) family.
应用
DIF-3 has been used: as a glycogen synthase kinase-3β (GSK-3β) activator to determine if GSK-3β is required for the anti-inflammatory actions of VU0360172 (VuPAM) in murine microglia, as a phosphorylation inhibitor for GSK-3β to examine the links between activation of protein kinase B (PKB)/GSK-3β/Fyn axis and nuclear factor erythroid 2–related factor 2 (NRF2) retention, as a GSK3β activator to study its effects on the cyclooxygenase 2 (COX2) expression levels in human primary chondrocytes in response to visfatin, as a GSK3β activator to study its effects on the intracellular mechanics along with F-actin and β-tubulin fiber networks in human primary chondrocytes
生化/生理作用
DIF-3 Inhibits cell cycle by inducing G0/G1 arrest.
Differentiation-inducing factor-3 (DIF-3) prevents the proliferation of intestinal cancer cells in vitro and in vivo. It may serve as a novel anti-cancer agent.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Effects of Visfatin on Intracellular Mechanics and Catabolism in Human Primary Chondrocytes through Glycogen Synthase Kinase 3 beta Inactivation
Chang SF, et al.
International Journal of Molecular Sciences, 22(15), 8107-8107 (2021)
The search for morphogens in Dictyostelium.
L Bloom et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 9(6), 187-191 (1988-12-01)
M Wang et al.
Developmental biology, 140(1), 182-188 (1990-07-01)
Stalk cell differentiation in Dictyostelium can be induced by the differentiation-inducing factor, DIF, or by conditions that decrease intracellular pH (pHi). We have investigated whether cytoplasmic acidification acts directly to induce expression of pDd56 and pDd63, two DIF-regulated genes, specifically
Junko Nakajima-Shimada et al.
Biochemical pharmacology, 85(11), 1603-1610 (2013-03-21)
Chagas disease (human American trypanosomiasis), which is caused by the protozoan parasite Trypanosoma cruzi, is responsible for numerous deaths each year; however, established treatments for the disease are limited. Differentiation-inducing factor-1 (DIF-1) and DIF-3 are chlorinated alkylphenones originally found in
A Sobolewski et al.
Developmental biology, 127(2), 296-303 (1988-06-01)
In Dictyostelium discoideum stalk cell formation is induced by cyclic AMP and differentiation-inducing factor (DIF) when cells are plated in in vitro monolayers (Kay et al., 1979, Differentiation 13: 7-14). The in vivo developmental stages at which cells became independent
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