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Merck
CN

D133

Sigma-Aldrich

6,7-Dichloroquinoxaline-2,3-dione

别名:

6,7-Dichloro-2,3-quinoxalinedione, DCQX

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关于此项目

经验公式(希尔记法):
C8H4Cl2N2O2
化学文摘社编号:
分子量:
231.04
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
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SMILES字符串

Clc1cc2NC(=O)C(=O)Nc2cc1Cl

InChI

1S/C8H4Cl2N2O2/c9-3-1-5-6(2-4(3)10)12-8(14)7(13)11-5/h1-2H,(H,11,13)(H,12,14)

InChI key

AVBSIKMUAFYZAV-UHFFFAOYSA-N

生化/生理作用

Antagonist at the NMDA glutamate receptor glycine site.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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R R Matsumoto et al.
European journal of pharmacology, 338(3), 233-242 (1998-01-10)
N-Methyl-D-aspartate (NMDA)/glycine site antagonists were tested for their ability to prevent cocaine-induced convulsions and lethality in Swiss Webster mice. Pre-treatment of mice with the novel NMDA/glycine site antagonists ACEA-1021 (5-nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione) or ACEA-1328 (5-nitro-6,7-dimethyl-1,4-dihydro-2,3-quinoxalinedione) attenuated cocaine-induced convulsions; these effects were pharmacologically
K Ogita et al.
Journal of neurochemistry, 54(2), 699-702 (1990-02-01)
Multiple binding sites on the N-methyl-D-aspartate (NMDA) receptor complex were examined using rat brain synaptic membranes treated with Triton X-100. Binding of [3H](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imi ne ([3H]MK-801), a noncompetitive NMDA antagonist, in the presence of 10 microM L-glutamate not only was inhibited

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