D1415
4,6-二氧庚酸
powder
别名:
琥珀酰丙酮
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关于此项目
线性分子式:
CH3COCH2COCH2CH2CO2H
化学文摘社编号:
分子量:
158.15
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
产品名称
4,6-二氧庚酸, powder
InChI key
WYEPBHZLDUPIOD-UHFFFAOYSA-N
SMILES string
CC(=O)CC(=O)CCC(O)=O
InChI
1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11)
form
powder
mp
66-67 °C (lit.)
lipid type
saturated FAs
storage temp.
2-8°C
Quality Level
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Application
4,6-二氧庚酸已用于：
- 作为树突状细胞条件培养基组分并抑制树突状细胞中的ALA脱水酶(ALAD)(50)
- 作为人单个核细胞(51)和HeLa细胞(52)中的血红素的生物合成抑制剂
- 作为恶性疟原虫培养物中的琥珀酰丙酮的定量标准品(53)
Biochem/physiol Actions
4,6-二氧庚酸是一种血红素生物合成抑制剂。它是酪氨酸分解的代谢副产物，可抑制δ氨基酮戊酸(ALA)脱水酶。它是检测酪氨酸血症Ⅰ型的潜在标志物，是新生儿干血斑分析的检测目标。
血红素生物合成抑制剂
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
The effects of levulinic acid and 4, 6-dioxoheptanoic acid on the metabolism of etiolated and greening barley leaves
Meller E and Gassman ML
Plant Physiology, 67(4), 728-732 (1981)
lonp1-dependent Breakdown Of Mitochondrial 5-aminolevulinic Acid Synthase Protein By Heme In Human Liver Cells: 904
Tian Q, et al.
Hepatology, 54(4), 785A-785A (2011)
Naomi Pode-Shakked et al.
European journal of medical genetics, 63(6), 103901-103901 (2020-03-11)
Maple syrup urine disease is a rare autosomal-recessive aminoacidopathy, caused by deficient branched-chain 2-keto acid dehydrogenase (BCKD), with subsequent accumulation of branched-chain amino acids (BCAAs): leucine, isoleucine and valine. While most cases of MSUD are classic, some 20% of cases
C M Mak et al.
Hong Kong medical journal = Xianggang yi xue za zhi, 24(4), 340-349 (2018-03-03)
Hereditary channelopathies and cardiomyopathies are potentially lethal and are clinically and genetically heterogeneous, involving at least 90 genes. Genetic testing can provide an accurate diagnosis, guide treatment, and enable cascade screening. The genetic basis among the Hong Kong Chinese population
Hilde Laeremans et al.
JIMD reports, 53(1), 90-102 (2020-05-13)
Nitisinone is used to treat hereditary tyrosinemia type 1 (HT-1) by preventing accumulation of toxic metabolites, including succinylacetone (SA). Accurate quantification of SA during newborn screening is essential, as is quantification of both SA and nitisinone for disease monitoring and
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