D1415
4,6-二氧庚酸
powder
别名:
琥珀酰丙酮
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关于此项目
线性分子式:
CH3COCH2COCH2CH2CO2H
化学文摘社编号:
分子量:
158.15
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
form
powder
Quality Level
mp
66-67 °C (lit.)
lipid type
saturated FAs
storage temp.
2-8°C
SMILES string
CC(=O)CC(=O)CCC(O)=O
InChI
1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11)
InChI key
WYEPBHZLDUPIOD-UHFFFAOYSA-N
Application
4,6-二氧庚酸已用于：
- 作为树突状细胞条件培养基组分并抑制树突状细胞中的ALA脱水酶(ALAD)(50)
- 作为人单个核细胞(51)和HeLa细胞(52)中的血红素的生物合成抑制剂
- 作为恶性疟原虫培养物中的琥珀酰丙酮的定量标准品(53)
Biochem/physiol Actions
4,6-二氧庚酸是一种血红素生物合成抑制剂。它是酪氨酸分解的代谢副产物，可抑制δ氨基酮戊酸(ALA)脱水酶。它是检测酪氨酸血症Ⅰ型的潜在标志物，是新生儿干血斑分析的检测目标。
血红素生物合成抑制剂
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Hilde Laeremans et al.
JIMD reports, 53(1), 90-102 (2020-05-13)
Nitisinone is used to treat hereditary tyrosinemia type 1 (HT-1) by preventing accumulation of toxic metabolites, including succinylacetone (SA). Accurate quantification of SA during newborn screening is essential, as is quantification of both SA and nitisinone for disease monitoring and
C M Mak et al.
Hong Kong medical journal = Xianggang yi xue za zhi, 24(4), 340-349 (2018-03-03)
Hereditary channelopathies and cardiomyopathies are potentially lethal and are clinically and genetically heterogeneous, involving at least 90 genes. Genetic testing can provide an accurate diagnosis, guide treatment, and enable cascade screening. The genetic basis among the Hong Kong Chinese population
Succinylacetone as primary marker to detect tyrosinemia type I in newborns and its measurement by newborn screening programs
De Jesus V, et al.
Molecular Genetics and Metabolism, 113(1-2), 67-75 (2014)
Steve C C Shih et al.
Analytical chemistry, 84(8), 3731-3738 (2012-03-15)
Dried blood spot (DBS) samples on filter paper are surging in popularity as a sampling and storage vehicle for a wide range of clinical and pharmaceutical applications. For example, a DBS sample is collected from every baby born in the
C Jakobs et al.
Clinica chimica acta; international journal of clinical chemistry, 171(2-3), 223-231 (1988-02-15)
A sensitive and accurate isotope dilution assay using electron capture negative ion mass fragmentography was developed for succinylacetone in amniotic fluid, plasma and urine. The method utilizes (D4)-5(3)-methyl-3(5)-isoxasole propionic acid as internal standard. Sample pretreatment consisted of oximation at pH
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D1415-1G | 04061833559888 |
| D1415-500MG | 04061832862002 |
| D1415-100MG | 04061833559871 |
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