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D1944

D4476

Name: D4476
Brand: SIGMA

≥98% (HPLC), solid

别名:

4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide

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关于此项目

经验公式（希尔记法）:

C₂₃H₁₈N₄O₃

化学文摘社编号:

301836-43-1

分子量:

398.41

MDL number:

MFCD28391149

UNSPSC Code:

12352200

PubChem Substance ID:

329798715

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

light yellow

solubility

DMSO: ~20 mg/mL, H₂O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

NC(=O)c1ccc(cc1)-c2nc(-c3ccccn3)c([nH]2)-c4ccc5OCCOc5c4

InChI

1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)

InChI key

DPDZHVCKYBCJHW-UHFFFAOYSA-N

说明

Application

D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.

Biochem/physiol Actions

D4476 may prevent or enhance apoptosis. It triggers tumor suppressor p53 and impairs transcription factor E2F-1.

D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1).

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Serine 235 is the primary NS5A hyperphosphorylation site responsible for hepatitis C virus replication

Hsu SC, et al.

Journal of Virology, 91(14), e00194-e00117 (2017)

Type I Interferons Control Proliferation and Function of the Intestinal Epithelium.

Yuliya V Katlinskaya et al.

Molecular and cellular biology, 36(7), 1124-1135 (2016-01-27)

Wnt pathway-driven proliferation and renewal of the intestinal epithelium must be tightly controlled to prevent development of cancer and barrier dysfunction. Although type I interferons (IFN) produced in the gut under the influence of microbiota are known for their antiproliferative

CK1alpha suppresses lung tumour growth by stabilizing PTEN and inducing autophagy

Cai J, et al.

Nature Cell Biology, 20(4), 465-465 (2018)

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全球贸易项目编号

货号	GTIN
D1944-1MG	04061826132005
D1944-5MG	04061832445359