推荐产品
生物来源
synthetic (organic)
质量水平
检测方案
≥98%
形式
powder
mp
259-262 °C (lit.)
溶解性
water: 50 mg/mL, clear to hazy, colorless to light yellow
储存温度
−20°C
SMILES字符串
CN(C)c1ncnc2[nH]cnc12
InChI
1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)
InChI key
BVIAOQMSVZHOJM-UHFFFAOYSA-N
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一般描述
6-二甲氨基嘌呤(6-DMAP)是一种嘌呤类代谢物，含有2个缩合杂环及与腺嘌呤的嘌呤氨基（环外氨基）连接的2个甲基。
应用
6-二甲氨基嘌呤已用于：
- 作为GR-1 aa培养基（牛培养基）补充剂，用于牛卵母细胞的孤雌激活，以研究其对胚胎发育的影响
- 核移植胚胎生产中的激活步骤
- 作为HCR2aa培养基补充剂，用于激活通过异种体细胞核移植(iSCNT)技术获得的异种胚胎
生化/生理作用
6-二甲氨基嘌呤(6-DMAP)是一种蛋白激酶和细胞周期蛋白依赖性激酶抑制剂。它是一种次生代谢产物，介导RNA修饰。6-DMAP是一种强效的细胞质分裂抑制剂，用于孤雌生殖和减数分裂研究。它也可用于促进哺乳动物卵母细胞的前核形成。根据飞秒荧光上转换光谱技术，6-DMAP是一种双荧光(dual fluorescence)分子。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
S Bhojwani et al.
Theriogenology, 67(2), 341-345 (2006-09-27)
The aim of the present investigation was to study the effect of oocyte selection on the efficiency of bovine nuclear transfer in terms of increased blastocyst production. For this purpose, prior to in vitro maturation (IVM), oocytes were selected for
Kyung H Chang et al.
Fertility and sterility, 80(6), 1380-1387 (2003-12-12)
To establish an interspecies somatic cell nuclear transfer (iSCNT) technique for deriving blastocysts having human chromosome complements without sacrificing human oocytes. Prospective, randomized study undertaken in vitro. University-affiliated hospital and laboratory, Seoul National University. Postpartum women with natural spontaneous vaginal
FTIR and FT-Raman spectra of 6-(dimethylamino) purine and its theoretical studies of anharmonic vibrational analysis using quantum chemical calculations
Faizan M and Ahmad S
Vibrational Spectroscopy, 113, 103224-103224 (2021)
Lizhi Leng et al.
Scientific reports, 7(1), 4242-4242 (2017-06-28)
A diploid genome is necessary for normal mammalian development, thus haploid parthenogenetic embryos undergo frequent self-diploidization during preimplantation development; however, the underlying mechanism is unclear. In this study, time-lapse recording revealed that human haploid parthenotes (HPs) undergo self-diploidization via failed
Y-p Hou et al.
Theriogenology, 72(5), 643-649 (2009-07-07)
The objective was to compare various activation protocols on developmental potential of vitrified bovine oocytes. Bovine oocytes matured in vitro for 23 h were vitrified with EDFSF30 in open pulled straws. After warming, they were cultured in vitro for 1h
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