D2667
2,5-Dihydroxycinnamic acid methyl ester
≥95%, crystalline
别名:
Erbstatin analog, Methyl 2,5-dihydroxycinnamate
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关于此项目
经验公式（希尔记法）:
C10H10O4
化学文摘社编号:
分子量:
194.18
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C10H10O4/c1-14-10(13)5-2-7-6-8(11)3-4-9(7)12/h2-6,11-12H,1H3/b5-2+
SMILES string
COC(=O)\C=C\c1cc(O)ccc1O
InChI key
BQCNSTFWSKOWMA-GORDUTHDSA-N
assay
≥95%
form
crystalline
color
yellow
mp
181-183 °C
solubility
0.1 M NaOH: soluble, H2O: insoluble, methanol: soluble
storage temp.
−20°C
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Biochem/physiol Actions
Inhibitor of EGF receptor-associated tyrosine kinase.
Other Notes
Stable analog of erbstatin.
Disclaimer
Photosensitive.
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
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C Y Liu et al.
The American journal of physiology, 270(6 Pt 1), C1825-C1833 (1996-06-01)
Although tyrosine kinases play an important role in cell growth and have been implicated in regulation of smooth muscle contraction, their role in agonist-induced myoplasmic Ca2+ responses is unclear. We examined effects of the tyrosine kinase inhibitors genistein and methyl
U Kralisz et al.
Thrombosis research, 86(4), 287-299 (1997-05-15)
Herbimycin A, lavendustin A, and methyl 2,5-dihydroxycinnamate were used to study the role of protein tyrosine kinases in collagen-platelet interaction. All three compounds produced a concentration dependent inhibition of platelet aggregation induced by collagen type I, characterized by values of
A Frew et al.
Allergy, 53(2), 139-143 (1998-04-16)
Occupational asthma due to western red cedar is associated with histamine release from basophils and mast cells on exposure to plicatic acid (PA), but the mechanisms underlying this response remain unclear. Specific kinase inhibitors were used to study the role
T H Jones et al.
The Journal of clinical endocrinology and metabolism, 82(7), 2143-2147 (1997-07-01)
Tyrosine kinases are involved in the phosphorylation of proteins that regulate cell growth and proliferation. The mitogenic effect of several growth factors requires tyrosine kinase activity of their receptors. The effect of inhibition of tyrosine kinase activity on thymidine uptake
O S Ruiz et al.
The Journal of membrane biology, 162(3), 201-208 (1998-05-16)
We examined the effect of respiratory acidosis on the Na-HCO3 cotransporter activity in primary cultures of the proximal tubule of the rabbit exposed to 10% CO2 for 5 min, 2, 4, 24 and 48 hr. Cells exposed to 10% CO2
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