D2943
Monoclonal Anti-PARK7 (DJ-1) antibody produced in mouse
~2 mg/mL, clone E2.1, purified immunoglobulin, buffered aqueous solution
别名:
Anti-Oncogene DJ1, Anti-Parkinson Disease (Autosomal Recessive, Early Onset) 7
生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
E2.1, monoclonal
表单
buffered aqueous solution
种属反应性
human
浓度
~2 mg/mL
技术
immunohistochemistry: suitable
western blot: 0.5-1.0 μg/mL using total cell extract of HEK 293T cells
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... PARK7(11315)
免疫原
full-length recombinant human DJ-1 protein.
应用
Monoclonal Anti-PARK7 (DJ-1) antibody produced in mouse is suitable for immunohistochemistry and western blot at a concentration of 0.5-1.0μg/mL using total cell extract of HEK 293T cells.
生化/生理作用
PARK7 is a member of novel glyoxalase family. It exerts mitochondrial activity. It has been suggested that PARK7 may act as an antioxidant and/or a molecular chaperone. It may also detoxify aggressive metabolic aldehyde by-products. It helps in stabilizing mitochondria during cellular stress. Alteration in gene function affects neurodegeneration, which leads to the autosomal recessive early-onset parkinsonism.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Yaacov Hod
Journal of cellular biochemistry, 92(6), 1221-1233 (2004-07-20)
DJ-1 is a conserved protein reported to be involved in diverse cellular processes ranging from cellular transformation, control of protein-RNA interaction, oxidative stress response to control of male infertility, among several others. Mutations in the human gene have been shown
Huw R Morris
Annals of medicine, 37(2), 86-96 (2005-07-20)
Twenty years ago Parkinson's disease (PD) was thought of as an environmentally determined neurodegenerative disease. It is now known that there are two autosomal dominant disease genes, alpha-synuclein and dardarin, and three genes responsible for autosomal recessive PD, parkin, DJ-1
Mark R Cookson
Annual review of biochemistry, 74, 29-52 (2005-06-15)
Several genes have been identified for monogenic disorders that variably resemble Parkinson's disease. Dominant mutations in the gene encoding alpha-synuclein enhance the propensity of this protein to aggregate. As a consequence, these patients have a widespread disease with protein inclusion
Darren J Moore et al.
Annual review of neuroscience, 28, 57-87 (2005-07-19)
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Although the etiology of PD is incompletely understood, the recent discovery of genes associated with rare monogenic forms
V Bonifati et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 24(3), 159-160 (2003-11-05)
Four chromosomal loci ( PARK2, PARK6, PARK7, and PARK9) associated with autosomal recessive, early onset parkinsonism are known. We mapped the PARK7 locus to chromosome 1p36 in a large family from a genetically isolated population in the Netherlands, and confirmed
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