D3876
2′-脱氧尿苷 5′-单磷酸 二钠盐
≥98% (HPLC), synthetic (organic), powder
别名:
dUMP
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关于此项目
线性分子式:
C9H11N2O8PNa2
化学文摘社编号:
分子量:
352.15
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
产品名称
2′-脱氧尿苷 5′-单磷酸 二钠盐, Sigma Grade
生物来源
synthetic (organic)
质量水平
等级
Sigma Grade
方案
≥98% (HPLC)
表单
powder
溶解性
water: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
[Na].OC1CC(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O
InChI
1S/C9H13N2O8P.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17);;
InChI key
WXIVKKBDJOCRNB-UHFFFAOYSA-N
相关类别
一般描述
2′-脱氧尿苷5′-单磷酸二钠盐（dUMP）是胸苷酸合酶的底物，并转化为脱氧胸苷单磷酸（dTMP）。
应用
2′-脱氧尿苷-5′-单磷酸二钠盐已用于：
- 超高效液相色谱-串联质谱（UPLC/MS/MS）法测定
- 刺激暴露于流行性感冒病毒抗原人外周血单个核细胞（PBMC）的增殖
- 胸苷酸合成酶活性测定幽门螺杆菌
苷酸合成酶（TS）（EC 2.1.1.45）使用2′-脱氧尿苷5′-单磷酸（dUMP）从头生产dTMP。在潜在的化疗应用中研究dUMP类似物时，将dUMP用作参考底物。
生化/生理作用
甲氨蝶呤可抑制2′-脱氧尿苷5′-单磷酸二钠盐（dUMP）转化为嘧啶。在甲基化步骤中将dUMP抑制为脱氧胸苷单磷酸（dTMP）是控制细菌和真核细胞生长的关键。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion
Holen E, et al.
Nutrition, 21(10), 1003-1009 (2005)
Abalo Chango et al.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 18(2), 81-84 (2009-02-11)
To develop a method for the simultaneous measurement of 5-methylcytosine (5-metC) and 2'-deoxyuridine monophosphate (dU). Genomic DNA was extracted from the HepG2 cell line grown in experimental complete medium or in folate-depleted medium. Samples were treated with RNAse A and
Biochemistry: Anchors away.
Maria Paola Costi et al.
Nature, 458(7240), 840-841 (2009-04-17)
Przemysław Ziemkowski et al.
Biochemical and biophysical research communications, 362(1), 37-43 (2007-08-19)
A series of 2'-fluoro-substituted dUMP/FdUMP analogues were synthesized, their interaction with human recombinant thymidylate synthase investigated, and structural (1)H and (19)F NMR study of the corresponding nucleosides performed. While 2'-F-dUMP (fluorine in the "down" configuration), in striking contrast to 2'-F-ara-UMP
Zachary Newby et al.
Biochemistry, 45(24), 7415-7428 (2006-06-14)
The enzyme thymidylate synthase (TS) catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to 2'-deoxythymidine 5'-monophosphate. Using kinetic and X-ray crystallography experiments, we have examined the role of the highly conserved Tyr-261 in the catalytic mechanism of TS. While Tyr-261
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