所有图片(4)
别名:
dUMP
线性分子式:
C9H11N2O8PNa2
CAS号:
分子量:
352.15
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
推荐产品
生物来源
synthetic (organic)
质量水平
等级
Sigma Grade
检测方案
≥98% (HPLC)
形式
powder
储存温度
−20°C
SMILES字符串
[Na].OC1CC(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O
InChI
1S/C9H13N2O8P.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17);;
InChI key
WXIVKKBDJOCRNB-UHFFFAOYSA-N
相关类别
一般描述
2′-脱氧尿苷5′-单磷酸二钠盐（dUMP）是胸苷酸合酶的底物，并转化为脱氧胸苷单磷酸（dTMP）。
应用
2′-脱氧尿苷-5′-单磷酸二钠盐已用于：
- 超高效液相色谱-串联质谱（UPLC/MS/MS）法测定
- 刺激暴露于流行性感冒病毒抗原人外周血单个核细胞（PBMC）的增殖
- 胸苷酸合成酶活性测定幽门螺杆菌
苷酸合成酶（TS）（EC 2.1.1.45）使用2′-脱氧尿苷5′-单磷酸（dUMP）从头生产dTMP。在潜在的化疗应用中研究dUMP类似物时，将dUMP用作参考底物。
生化/生理作用
甲氨蝶呤可抑制2′-脱氧尿苷5′-单磷酸二钠盐（dUMP）转化为嘧啶。在甲基化步骤中将dUMP抑制为脱氧胸苷单磷酸（dTMP）是控制细菌和真核细胞生长的关键。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Abalo Chango et al.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 18(2), 81-84 (2009-02-11)
To develop a method for the simultaneous measurement of 5-methylcytosine (5-metC) and 2'-deoxyuridine monophosphate (dU). Genomic DNA was extracted from the HepG2 cell line grown in experimental complete medium or in folate-depleted medium. Samples were treated with RNAse A and
Peter S Ludwig et al.
European journal of medicinal chemistry, 40(5), 494-504 (2005-05-17)
Amphiphilic anticancer prodrugs of 5'-fluoro-2'-deoxyuridine-5'-monophosphate (5-FdUMP) were synthesized according to the hydrogen phosphonate method by coupling lipophilic cytosine derivatives or a phospholipid with 5-fluoro-2'-deoxyuridine (5-FdU). Studies within the in vitro Anticancer Screen Program of the National Cancer Institute have demonstrated
Dimitri Topalis et al.
The FEBS journal, 272(24), 6254-6265 (2005-12-13)
Anti-poxvirus therapies are currently limited to cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine], but drug-resistant strains have already been characterized. In the aim of finding a new target, the thymidylate (TMP) kinase from vaccinia virus, the prototype of Orthopoxvirus, has been overexpressed in Escherichia coli
Xiaoli Zhang et al.
Protein and peptide letters, 19(11), 1225-1230 (2012-04-20)
ThyX, a flavin-dependent thymidylate synthase that is involved in the synthesis of dTMP from dUMP, is a promising target for the development of novel antibacterial drugs that aimed at blocking the biosynthesis of dTMP, one of the building blocks of
Biochemistry: Anchors away.
Maria Paola Costi et al.
Nature, 458(7240), 840-841 (2009-04-17)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门