D7911
癸基泛醌
≥97% (HPLC)
别名:
2,3-二甲氧基-5-甲基-6-癸基-1,4-苯醌
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关于此项目
经验公式（希尔记法）:
C19H30O4
CAS Number:
分子量:
322.44
MDL编号:
UNSPSC代码:
12162212
PubChem化学物质编号:
NACRES:
NA.25
质量水平
方案
≥97% (HPLC)
表单
liquid
储存温度
−20°C
SMILES字符串
CCCCCCCCCCC1=C(C)C(=O)C(OC)=C(OC)C1=O
InChI
1S/C19H30O4/c1-5-6-7-8-9-10-11-12-13-15-14(2)16(20)18(22-3)19(23-4)17(15)21/h5-13H2,1-4H3
InChI key
VMEGFMNVSYVVOM-UHFFFAOYSA-N
一般描述
泛醌类似物。
线粒体通透性转换孔 (MPTP) 抑制剂。
应用
- 作为钯诱导脂肪毒性中介物的溶酶体钙（2+）。: 该研究探索了癸基泛醌（decylubiquinone）在调节溶酶体钙（2+）水平中的作用，提供了有关脂肪毒性机制和代谢疾病潜在治疗应用的见解（Oh et al., 2023）。
- VI型硫化物中的醌结合位点:醌氧化还原酶。：该论文研究了癸基泛醌在硫化物:醌氧化还原酶中的结合动力学,阐明了其在微生物呼吸中的作用和潜在生物技术应用（Miklovics et al., 2022）。
- 癸基泛醌对B16F10诱导小鼠中继发性黑色素瘤的保护作用。: 该研究展示了癸基泛醌在黑色素瘤小鼠模型中的抗转移性质，重点介绍了其成为癌症治疗中治疗药的潜力（Chatterjee et al., 2023）。
- 癸基泛醌通过上调Sirtuin2来抑制结肠直肠癌细胞生长。: 该研究确认了癸基泛醌是通过调节Sirtuin2表达，而成为结肠直肠癌细胞生长的抑制剂，研究暗示了其在癌症治疗中的应用（Li et al., 2021）。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yasser Ahmed Mahmmoud et al.
The Journal of biological chemistry, 280(30), 27776-27782 (2005-05-28)
FXYD domain-containing proteins are tissue-specific regulators of the Na,K-ATPase that have been shown to have significant physiological implications. Information about the sites of interaction between some FXYD proteins and subunits of the Na,K-ATPase is beginning to emerge. We previously identified
Hongzhi Li et al.
Biochimica et biophysica acta, 1863(9), 2266-2273 (2017-06-01)
Our previous study generated a series of cybrids containing mitochondria of synaptosomes from mice at different ages. The following functional analysis on these cybrids revealed an age-dependent decline of mitochondrial function. To understand the underlying mechanisms that contribute to the
Zeqi Zheng et al.
International journal of nanomedicine, 15, 4501-4521 (2020-07-02)
Elevation of blood homocysteine (Hcy) level (hyperhomocysteinemia) is a risk factor for cardiovascular disorders and is closely associated with endothelial dysfunction. The present study aims to investigate the protective effect and underlying mechanism of nanoscale selenium (Nano-Se) in Hcy-mediated vascular
Hannah R Bridges et al.
Nature communications, 11(1), 5261-5261 (2020-10-18)
Respiratory complex I (NADH:ubiquinone oxidoreductase) captures the free energy from oxidising NADH and reducing ubiquinone to drive protons across the mitochondrial inner membrane and power oxidative phosphorylation. Recent cryo-EM analyses have produced near-complete models of the mammalian complex, but leave
Samuel S W Szeto et al.
The Journal of biological chemistry, 287(27), 22509-22520 (2012-05-11)
Succinate dehydrogenase (SDH), also known as complex II, is required for respiratory growth; it couples the oxidation of succinate to the reduction of ubiquinone. The enzyme is composed of two domains. A membrane-extrinsic catalytic domain composed of the Sdh1p and
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