D7911
癸基泛醌
≥97% (HPLC)
别名:
2,3-二甲氧基-5-甲基-6-癸基-1,4-苯醌
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关于此项目
经验公式（希尔记法）:
C19H30O4
化学文摘社编号:
分子量:
322.44
MDL编号:
UNSPSC代码:
12162212
PubChem化学物质编号:
NACRES:
NA.25
质量水平
方案
≥97% (HPLC)
表单
liquid
储存温度
−20°C
SMILES字符串
CCCCCCCCCCC1=C(C)C(=O)C(OC)=C(OC)C1=O
InChI
1S/C19H30O4/c1-5-6-7-8-9-10-11-12-13-15-14(2)16(20)18(22-3)19(23-4)17(15)21/h5-13H2,1-4H3
InChI key
VMEGFMNVSYVVOM-UHFFFAOYSA-N
一般描述
泛醌类似物。
线粒体通透性转换孔 (MPTP) 抑制剂。
应用
- 作为钯诱导脂肪毒性中介物的溶酶体钙（2+）。: 该研究探索了癸基泛醌（decylubiquinone）在调节溶酶体钙（2+）水平中的作用，提供了有关脂肪毒性机制和代谢疾病潜在治疗应用的见解（Oh et al., 2023）。
- VI型硫化物中的醌结合位点:醌氧化还原酶。：该论文研究了癸基泛醌在硫化物:醌氧化还原酶中的结合动力学,阐明了其在微生物呼吸中的作用和潜在生物技术应用（Miklovics et al., 2022）。
- 癸基泛醌对B16F10诱导小鼠中继发性黑色素瘤的保护作用。: 该研究展示了癸基泛醌在黑色素瘤小鼠模型中的抗转移性质，重点介绍了其成为癌症治疗中治疗药的潜力（Chatterjee et al., 2023）。
- 癸基泛醌通过上调Sirtuin2来抑制结肠直肠癌细胞生长。: 该研究确认了癸基泛醌是通过调节Sirtuin2表达，而成为结肠直肠癌细胞生长的抑制剂，研究暗示了其在癌症治疗中的应用（Li et al., 2021）。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Matthias L Jauslin et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17(13), 1972-1974 (2003-08-19)
Friedreich Ataxia (FRDA), the most common inherited ataxia, arises from defective expression of the mitochondrial protein frataxin, which leads to increased mitochondrial oxidative damage. Therefore, antioxidants targeted to mitochondria should be particularly effective at slowing disease progression. To test this
Klaudia Borysiuk et al.
Frontiers in plant science, 9, 667-667 (2018-06-09)
Nitrate (NO3-) and ammonium (NH4+) are prevalent nitrogen (N) sources for plants. Although NH4+ should be the preferred form of N from the energetic point of view, ammonium nutrition often exhibits adverse effects on plant physiological functions and induces an
Samuel S W Szeto et al.
The Journal of biological chemistry, 287(27), 22509-22520 (2012-05-11)
Succinate dehydrogenase (SDH), also known as complex II, is required for respiratory growth; it couples the oxidation of succinate to the reduction of ubiquinone. The enzyme is composed of two domains. A membrane-extrinsic catalytic domain composed of the Sdh1p and
Hongzhi Li et al.
Biochimica et biophysica acta, 1863(9), 2266-2273 (2017-06-01)
Our previous study generated a series of cybrids containing mitochondria of synaptosomes from mice at different ages. The following functional analysis on these cybrids revealed an age-dependent decline of mitochondrial function. To understand the underlying mechanisms that contribute to the
Yasser Ahmed Mahmmoud et al.
The Journal of biological chemistry, 280(30), 27776-27782 (2005-05-28)
FXYD domain-containing proteins are tissue-specific regulators of the Na,K-ATPase that have been shown to have significant physiological implications. Information about the sites of interaction between some FXYD proteins and subunits of the Na,K-ATPase is beginning to emerge. We previously identified
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