D8440
15-脱氧-Δ12,14-前列腺素J2
≥95% (HPLC), 1 mg/mL in methyl acetate
别名:
11-氧化前列素-（5Z,9,12E,14E）-四烯-1-酸, 15-脱氧-Δ12,14-PGJ2
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关于此项目
经验公式（希尔记法）:
C20H28O3
化学文摘社编号:
分子量:
316.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
EC Number:
201-185-2
MDL number:
Quality Level
assay
≥95% (HPLC)
form
liquid
concentration
1 mg/mL in methyl acetate
shipped in
wet ice
storage temp.
−20°C
SMILES string
CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O
InChI
1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1
InChI key
VHRUMKCAEVRUBK-GODQJPCRSA-N
General description
15-脱氧-Δ12，14-前列腺素J2（15d-PGJ2）是前列腺素J2（PGJ2）的代谢产物，是前列腺素D2的天然衍生物。它是在炎症过程中产生的。
Application
15-脱氧-Δ12，14-前列腺素J2已用于：
- 研究其对血管化脂肪组织模型中的脂质积累、活率/线粒体活性和脉管系统数量的效应
- 氧化物酶体增殖物激活受体（PPARγ）激动剂激活肠道脂肪酸结合蛋白（I-FABP）-PPARγ途径
- 作为培养培养基中的补充剂，用于诱导神经干细胞/祖细胞（NSPCs）分化
Biochem/physiol Actions
15-脱氧-Δ12，14-前列腺素J2（15d-PGJ2）调节体内炎症反应。15d-PGJ2还引起核因子（NF）-κB依赖性转录的PPARγ依赖性抑制。它作为抗血管生成的因子，并触发内皮细胞凋亡。
PPARγ（过氧化物酶体增殖物激活受体）的选择性激动剂。 抑制表达PPARγ和环氧合酶-2（COX-2）的癌细胞系的增殖。
Disclaimer
Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
target_organs
Central nervous system
supp_hazards
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
15.8 °F - closed cup
flash_point_c
-9 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves
法规信息
危险化学品
此项目有
15-Deoxy-$\Delta$ (12, 14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53
Ho TC, et al.
Test, 283(44), 30273-30288 (2008)
Gas chromatographic-mass spectrometric measurement of 15-deoxy-delta(12,14)-prostaglandin J(2), the peroxisome proliferator-activated receptor gamma ligand, in urine.
C Thévenon et al.
Clinical chemistry, 47(4), 768-770 (2001-03-29)
Min Zhao et al.
Oncotarget, 7(40), 64690-64701 (2016-09-08)
Accumulating evidence suggests that loss of the renal tubular epithelial phenotype plays an important role in the pathogenesis of renal tubulointerstitial fibrosis. Systemic activation of peroxisome proliferator-activated receptor γ (PPAR-γ) has been shown to be protective against renal fibrosis, although
M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPAR gamma signaling pathway
Yuan J, et al.
Oncotarget, 8(12), 19855-19855 (2017)
Mojgan Masoodi et al.
Rapid communications in mass spectrometry : RCM, 20(20), 3023-3029 (2006-09-21)
Prostanoids are potent mediators of many physiological and pathophysiological processes. Of the many analytical methodologies used for their qualitative and quantitative analysis, electrospray tandem mass spectrometry coupled to liquid chromatography (LC/ESI-MS/MS) offers a rapid, sensitive and versatile system applicable to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D8440-100UG | 04061838070760 |
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